Pentapeptide-1 (Thymopentin) (CAS 69558-55-0) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. A freely water-soluble peptide, it dissolves directly in aqueous concentrates without co-solvents at pH 5.0–7.5, with cool-down addition below 45°C recommended in standard serum and leave-on manufacturing protocols.
> Technical Specifications
| Product Name | Pentapeptide-1 (Thymopentin) |
|---|---|
| Molecular Structure |  |
| CAS Number | 69558-55-0 |
| Alias / Common Name | Pentapeptide-1; Thymopentin; Arg-Lys-Asp-Val-Tyr |
| Molecular Formula | C30H49N9O9 |
| Molecular Weight | 679.8 g/mol |
| INCI Name | Pentapeptide-1 |
| Peptide Sequence | Arg-Lys-Asp-Val-Tyr — RKDVY, thymopoietin domain-32-36 biomimetic (cutaneous immune-cell signalling) |
| Functional Class | Synthetic pentapeptide; thymopoietin-derived sequence; cutaneous immune-signalling modulator; age-care immunomodulator |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Freely water-soluble; dissolve in deionised water or aqueous phase at ambient temperature; no co-solvent required |
| pH Stability | Optimal stability at pH 5.0–7.5; confirm in the complete formulation after all actives |
| Storage | Store sealed below 25°C in cool, dry, light-protected conditions; follow batch COA and SDS |
> Mechanism & Positioning
Pentapeptide-1 (Thymopentin, Arg-Lys-Asp-Val-Tyr, CAS 69558-55-0) is a synthetic pentapeptide derived from the domain-32-36 sequence of thymopoietin, the thymic stroma hormone responsible for T-lymphocyte differentiation and maturation. Published Pentapeptide-1 (Thymopentin) literature discusses interaction with IL-2 receptor (CD25/IL-2Rα) and related cutaneous immune-cell signalling pathways on skin-resident Langerhans cells and keratinocytes, relevant to cutaneous immune homeostasis and immune-modulatory age-care positioning. Cell-based keratinocyte and Langerhans cell model studies document modulation of thymic factor-related cytokine signalling, with effects on immune-regulatory mediator output in skin cell assay systems. Immune-signalling model data also notes the RKDVY sequence interaction with IL-2-related receptor complexes in T-cell adjacent cell types, positioning Pentapeptide-1 for immune-supportive age-care formulation concepts where cutaneous immune homeostasis (impaired in photoaged and chronologically aged skin) is a secondary formulation direction.
Based on available in vitro data, Pentapeptide-1 (Thymopentin) is positioned for immune-modulating age-care serum, skin immunity support concentrate and regenerative leave-on formulation concepts. The thymopoietin-derived immune-signalling mechanism complements matrix-synthesis active positioning and may be combined with Matrixyl for simultaneous TGF-β1 matrix signalling and immune-modulatory age-care in a premium concentrate, alongside Ectoin for barrier and soothing support.
> Application Concepts
Immune-Modulating Age-Care Serum Architecture
Pentapeptide-1 (Thymopentin) dissolves freely in deionised water and aqueous serum bases at 10–1000 ppm without co-solvent. Introduce during the cool-down phase below 45°C; standard aqueous serum protocols are compatible. For immune-supportive age-care positioning, combine with Ectoin (1–3%, membrane stabilisation and TSLP modulation) and niacinamide (2–5%, calming Langerhans-cell support) for complementary cutaneous immune homeostasis across three independent pathways. Confirm pH alignment (5.0–7.0) across all actives and peptide assay retention by HPLC after accelerated stability at 40°C/75% RH before scale-up.
Combination with Matrix-Care and Anti-Aging Actives
Pentapeptide-1 (RKDVY) may be combined with matrix-synthesis actives for premium multi-mechanism age-care serum positioning covering both structural matrix renewal and cutaneous immune support. At 10–1000 ppm alongside Matrixyl (TGF-β1 collagen synthesis), GHK-Cu (LOX crosslinking) and Ergothioneine (mitochondrial antioxidant), a four-active age-care serum addresses structural, energetic and immune dimensions of skin aging. All four are freely water-soluble and pH-compatible at 5.0–7.5. Confirm combined pH, clarity and assay retention before production scale-up.
Regenerative and Post-Procedure Immune-Support Formulations
The thymopoietin-derived immune-modulating activity of Pentapeptide-1 makes it relevant for post-procedure formulations where Langerhans cell recovery and cutaneous immune normalisation after laser, peel or microneedling are key recovery objectives. At 10–1000 ppm in a soothing serum or gel concentrate, Pentapeptide-1 supports immune-cell signalling alongside calming actives (bisabolol, panthenol, allantoin) and barrier-repair actives (ceramide NP, Ectoin). Post-procedure serums benefit from water-soluble, high-purity peptide actives that can be formulated in minimal-excipient bases — Pentapeptide-1 is compatible with this positioning. Confirm combined stability and pH alignment in the target post-procedure base before scale-up.
> Handling & Formulation Notes
Dissolve Pentapeptide-1 (Thymopentin) in deionised water or the aqueous phase at ambient temperature at 10–1000 ppm without co-solvent. Freely water-soluble and stable at standard processing temperatures. Introduce during the cool-down phase below 45°C. Maintain formulation pH within 5.0–7.5.
Evaluate compatibility with standard preservative systems and chelating agents at typical cosmetic concentrations. Confirm peptide assay retention by HPLC after accelerated stability testing at 40°C/75% RH before production scale-up.
> Supply & Documentation
Pentapeptide-1 (Thymopentin) (CAS 69558-55-0) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Pentapeptide-1 (Thymopentin) is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Pentapeptide-1 (Thymopentin)?
Pentapeptide-1 (Thymopentin) (CAS 69558-55-0) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Pentapeptide-1 (Thymopentin) is positioned as a thymopoietin-derived immunomodulatory pentapeptide that modulates T-cell differentiation signals in the skin — evaluated in anti-ageing and skin-restoration serums targeting age-related immunosenescence and the decline in immunosurveillance that contributes to cumulative UV damage and reduced skin repair. TCS NEXUS S.L. supplies Pentapeptide-1 as a B2B active for formulators developing immunological and anti-ageing leave-on products.
What is the CAS number for Pentapeptide-1 (Thymopentin)?
The CAS number for Pentapeptide-1 (Thymopentin) is 69558-55-0. The INCI name for cosmetic regulatory documentation and CPNP notification is Pentapeptide-1; confirm CAS 69558-55-0 and INCI identity against the batch COA when building product files.
How does Pentapeptide-1 (Thymopentin) support skin — what is the immune-signalling mechanism?
Pentapeptide-1 (Thymopentin) is Arg-Lys-Asp-Val-Tyr (RKDVY), a biomimetic of the active domain (residues 32–36) of thymopoietin, a thymic immune-signalling protein. In skin it is discussed as modulating cutaneous immune-cell signalling to support the skin’s resilience and balance with age, positioning it as an immunomodulatory age-care peptide rather than a direct collagen or expression-line active.
What use level of Pentapeptide-1 is typical, and how should it be evaluated?
There is no one-size-fits-all dose: establish the use level conservatively for your base and claim; it is often a trade solution, so confirm your dosing basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Pentapeptide-1 in a resilience age-care system?
Pentapeptide-1 (immune-signalling support) complements matrix peptides such as Matrixyl and GHK-Cu, soothing actives and antioxidants for a resilience-focused age-care system. It is water-soluble; confirm combined stability and pH in the finished base.
What makes Pentapeptide-1 distinct — the thymopoietin immune angle?
Its distinctive angle is the thymopoietin-derived immune-signalling sequence: rather than building collagen or relaxing muscle, it is positioned to support cutaneous immune balance and resilience with age. That makes it a complementary “skin fitness” partner to structural and soothing peptides. Pentapeptide-1 is freely water-soluble.
What addition temperature is recommended for Pentapeptide-1 (Thymopentin) during manufacturing?
Introduce Pentapeptide-1 (Thymopentin) during the cool-down phase at temperatures below 45°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Pentapeptide-1 stable in a finished formula?
Pentapeptide-1 is most stable at roughly pH 4.5–7.0; confirm the finished-product pH after all actives are incorporated and evaluate combined stability in the complete base.
Is Pentapeptide-1 (Thymopentin) compatible with other actives in multi-active cosmetic systems?
Pentapeptide-1 (Thymopentin) is compatible with standard cosmetic actives at pH 5.0–7.5 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Pentapeptide-1 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Pentapeptide-1 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 69558-55-0 and INCI name Pentapeptide-1 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Pentapeptide-1 (Thymopentin) be stored?
Store Pentapeptide-1 (Thymopentin) sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Pentapeptide-1 (Thymopentin)?
TCS NEXUS S.L. provides COA (confirming CAS 69558-55-0 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Pentapeptide-1 (Thymopentin). Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Pentapeptide-1 (Thymopentin)?
Sample and bulk quantities for Pentapeptide-1 (Thymopentin) are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.