Acetyl Hexapeptide-38: Volumizing Peptide for Lip and Facial Contouring
Acetyl Hexapeptide-38 (CAS 1400634-44-7) is a bioactive hexapeptide engineered for non-invasive lip volumization and facial soft-tissue contouring. This peptide targets adipogenesis pathways, making it one of the few cosmetic actives capable of stimulating localized volume enhancement without dermal fillers. TCS NEXUS S.L. supplies Acetyl Hexapeptide-38 from our warehouse in Valencia, Spain.
Mechanism of Action
Acetyl Hexapeptide-38 activates the VGEF (Vascular Endothelial Growth Factor) signaling cascade in pre-adipocytes, promoting their differentiation into mature adipocytes. The peptide binds to specific receptors on mesenchymal stem cells within the dermal-subcutaneous junction, triggering PPAR-gamma transcription factor activation. This molecular pathway drives lipid droplet accumulation and adipocyte maturation in targeted tissue areas, resulting in measurable volume increases in treated regions such as the lips and cheekbones.
Cosmetic Efficacy Data
In controlled efficacy panels, Acetyl Hexapeptide-38 demonstrated significant volumizing activity. At a concentration of 2% in a lip-care emulsion, treated subjects exhibited an 18% increase in lip volume score over 56 days compared to placebo. Three-dimensional profilometry confirmed the volume changes, with particular improvements noted in the vermillion border definition and overall lip fullness. Participant self-assessment scores for lip plumpness and contour improved by 22% within the same study period.
Formulation Guidelines
Acetyl Hexapeptide-38 is typically incorporated at 1-3% in finished cosmetic formulations. The peptide demonstrates optimal stability at pH 5.0-6.5 and is compatible with standard emulsion systems, liposomal delivery vehicles, and hydrogel matrices. For lip-specific products, formulators often combine Acetyl Hexapeptide-38 with hyaluronic acid crosspolymers for immediate plumping effects alongside the peptide-driven long-term volumization. The ingredient integrates well into lip balms, lip serums, cheek contouring creams, and facial volumizing treatments.
Applications in Cosmetic Development
- Lip volumizing serums and balms targeting non-invasive plumping
- Facial contouring creams for cheekbone and jawline definition
- Anti-aging formulations addressing age-related volume loss
- Decollete and hand treatments for tissue density improvement
- Combined protocols with Palmitoyl Tripeptide-38 for collagen plus volume
Quality and Supply from TCS NEXUS S.L.
As a dedicated Acetyl Hexapeptide-38 supplier in Europe, TCS NEXUS S.L. provides this peptide with full regulatory documentation including Certificate of Analysis, MSDS, and COSMOS compliance certificates. Each production lot undergoes HPLC purity verification and mass spectrometry confirmation.
Ordering and Minimum Quantities
Evaluation samples start from 1g for formulation development and stability testing. Production orders begin at 100g with volume-based pricing available for recurring supply agreements. All shipments include cold-chain packaging where required, with standard delivery across the European Union within 3-5 business days. Contact our peptide specialists for custom purity grades or specific salt forms tailored to your formulation requirements.
Technical Profile
Acetyl Hexapeptide-38 is a lipogenesis-stimulating peptide that promotes adipocyte differentiation, making it a specialized active for lip-plumping, facial volumizing, and contour-enhancing cosmetic formulations.
Best-Fit Applications
- Lip-care and contour-enhancement product concepts
- Premium volumizing and facial-definition formulas
- Projects seeking differentiated peptide positioning in crowded categories
Related Peptide Portfolio: TCS NEXUS supplies a connected range of anti-aging, brightening, repair, and matrix-support peptides for cosmetic formulators across Europe.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.