Acetyl Hexapeptide-38 (Adifyline) (CAS 1400634-44-7) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. A freely water-soluble peptide, it dissolves directly in aqueous concentrates without co-solvents at pH 4.5–7.0, with cool-down addition below 40°C recommended in standard serum and leave-on manufacturing protocols.
> Technical Specifications
| Product Name | Acetyl Hexapeptide-38 (Adifyline) |
|---|---|
| Molecular Structure |  |
| CAS Number | 1400634-44-7 |
| Alias / Common Name | Acetyl Hexapeptide-38; Adifyline; adipogenesis-promoting cosmetic hexapeptide |
| Molecular Formula | C30H55N9O10 |
| Molecular Weight | 701.8 g/mol |
| INCI Name | Acetyl Hexapeptide-38 |
| Peptide Sequence | Acetyl hexapeptide — Ac-XXHKFR sequence (adipogenesis stimulating hexapeptide) |
| Functional Class | Synthetic hexapeptide; adipogenesis modulator; subcutaneous fat pad volume support; lip volumising and facial padding active; PPARγ pathway active |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Freely water-soluble at evaluation concentrations (0.001–0.05%); dissolves directly in deionised water or the aqueous phase without co-solvent. Add at cool-down below 40°C. |
| pH Stability | Optimal stability at pH 4.5–7.0. Confirm stability in the complete formulation base. |
| Storage | Store sealed below 25°C in a cool, dry location protected from direct light and moisture. Follow SDS and batch COA conditions. |
> Mechanism & Positioning
Acetyl Hexapeptide-38 (Adifyline) is a synthetic hexapeptide designed to activate adipogenesis in dermal adipocytes and pre-adipocytes — a mechanism relevant to subcutaneous fat pad volume support for facial contouring and lip volumising applications. Published Acetyl Hexapeptide-38 literature discusses activation of the PPARγ (peroxisome proliferator-activated receptor gamma) pathway, the master transcriptional regulator of adipocyte differentiation and lipid droplet accumulation in preadipocyte-to-adipocyte conversion. Cell-based 3T3-L1 preadipocyte differentiation studies document increased PPARγ and C/EBPα gene expression, accelerated lipid droplet formation and increased triglyceride accumulation in treated preadipocyte cultures. Subcutaneous adipose tissue volume model data also notes increased adipocyte lipid storage capacity in dermal adipocyte layer models, consistent with the mechanism positioning Adifyline for lip volumising serums, cheek plumping concentrates and facial fat pad support products seeking cosmetic volume alternatives to injectable approaches. The water-soluble hexapeptide delivers the adipogenic signal without co-solvent, lipid carrier or encapsulation requirement at evaluation concentrations.
Acetyl Hexapeptide-38 builds volume-plumping and structural support systems with Palmitoyl Tripeptide-1 (Pal-GHK) for ECM fibronectin and collagen I support alongside subcutaneous volume activation, and with hyaluronic acid (high MW, 1.5–2 MDa) for immediate surface volumising effect complementing the longer-term dermal adipocyte pathway. For lip treatment positioning, evaluate alongside Acetyl Hexapeptide-8 (Argireline) for surface expression-line control alongside deep lip volume support. Contact info@tcspeptides.com with formulation specification.
> Application Concepts
Lip Volumising Serum and Adipogenesis Hexapeptide Architecture
Acetyl Hexapeptide-38 at 0.001–0.05% dissolves directly in deionised water and is added at cool-down below 40°C — a clean, straightforward addition to lip volumising serums, facial plumping concentrates and targeted contouring treatments. At pH 5.0–6.5, it is compatible with standard HA-based serum and gel-cream bases for lip and facial treatment formats. For a dual-mechanism lip volumising treatment, combine Acetyl Hexapeptide-38 (PPARγ / dermal adipocyte volume) with high-MW hyaluronic acid (1.5–2 MDa at 0.5–1%) for immediate surface plumping alongside the longer-term adipogenesis pathway, and add a peptide film-former (polyglutamic acid or sodium PCA) for sensorial lip fullness enhancement in the immediate-use positioning.
Adipogenesis Pathway vs ECM Volume — Two Distinct Approaches to Non-Injectable Facial Volumising
Cosmetic facial volume restoration targets two distinct structural compartments: the ECM scaffold (collagen/elastin network — supported by lipopeptides such as Palmitoyl Tripeptide-1) and the subcutaneous fat pad (adipocyte volume — supported by Acetyl Hexapeptide-38 via PPARγ adipogenesis activation). Volume loss in ageing involves both ECM thinning and fat pad atrophy in the malar, temporal and periorbital regions. A combined approach — matrix peptides for ECM scaffold restoration plus Acetyl Hexapeptide-38 for adipocyte volume support — addresses both compartments for more comprehensive structural anti-age positioning than ECM peptides alone. This is a mechanistically distinct non-injectable approach to the volume-loss component of facial ageing.
Lip Treatment, Facial Padding and Contouring Concentrate Format Applications
Acetyl Hexapeptide-38 is positioned for three volume-focused market segments: lip volumising serums and balms (dermal adipocyte volume support for lip area subcutaneous fat pad), facial padding concentrates (malar and temporal fat pad support for contouring without injection), and anti-ageing day creams including a structural volume claim alongside matrix peptide and antioxidant ingredients. For lip treatment formats, incorporate Acetyl Hexapeptide-38 at 0.001–0.05% in a sensorial lip gloss base (caster oil/polybutene/HA) alongside a physical lip plumping agent (peppermint oil 0.05%, niacin 0.1%) for immediate and long-term lip volume positioning. Confirm formulation compatibility between Adifyline and the lip base at pH 5.5–6.5 before scale-up.
> Handling & Formulation Notes
Dissolve Acetyl Hexapeptide-38 directly in deionised water or the aqueous phase at target concentrations (0.001–0.05%) without co-solvent or pre-dispersion step. Add the aqueous solution to the formulation at cool-down below 40°C. No PG pre-dispersion or special dissolution step is required at evaluation concentrations. For concentrations above 0.1%, prepare a 1% aqueous stock solution and add the calculated aliquot at cool-down.
Confirm stability of Acetyl Hexapeptide-38 (Adifyline) in the complete volumising formulation at 40°C/75% RH for 12 weeks before scale-up. Monitor peptide integrity by HPLC when formulating at pH outside 4.5–7.0 or in high-electrolyte bases. Follow SDS and batch COA for storage and handling. EDTA at ≤0.1% is compatible as a chelating buffer; avoid strong oxidising agents (H₂O₂ ≥1%, benzoyl peroxide) and high-pH systems above pH 8.0.
> Supply & Documentation
Acetyl Hexapeptide-38 (Adifyline) (CAS 1400634-44-7) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Acetyl Hexapeptide-38 (Adifyline) is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Acetyl Hexapeptide-38 (Adifyline)?
Acetyl Hexapeptide-38 (Adifyline) (CAS 1400634-44-7) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Adifyline is positioned as an adipogenesis-stimulating hexapeptide that restores dermal white adipose tissue (dWAT) volume beneath the dermis — evaluated in facial plumping and anti-ageing volumising serums where loss of subcutaneous fat contributes to visible sagging. TCS NEXUS S.L. supplies Acetyl Hexapeptide-38 as a pure acetylated hexapeptide for B2B cosmetic formulators.
What is the CAS number for Acetyl Hexapeptide-38 (Adifyline)?
The CAS number for Acetyl Hexapeptide-38 (Adifyline) is 1400634-44-7. The INCI name for cosmetic regulatory documentation and CPNP notification is Acetyl Hexapeptide-38; confirm CAS 1400634-44-7 and INCI identity against the batch COA when building product files.
How does Adifyline add volume — what is the adipogenesis / PPARγ mechanism?
Acetyl Hexapeptide-38 (Adifyline) is a hexapeptide discussed as a stimulator of adipogenesis through the PPARγ pathway, supporting the volume of the subcutaneous fat pad that gives skin its cushioned fullness. It is positioned for the cosmetic appearance of facial padding, plumpness and lip volume — an approach that adds soft-tissue volume rather than acting on collagen or the neuromuscular system.
What use level of Adifyline is typical, and how should it be evaluated?
Because the effective level shifts with formulation and claim, build it up conservatively from your own evaluation instead of fixing on one number; it is usually a trade solution, so confirm your dosing basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Adifyline in a volume and firmness system?
Adifyline (soft-tissue volume) complements collagen-matrix peptides such as Matrixyl and Palmitoyl Tripeptide-1 (structural support) and hydrators such as hyaluronic acid for a plumping, cushioned appearance, and it is used in lip and cheek volumising concepts. It is water-soluble; confirm combined stability and pH in the finished base.
What makes Acetyl Hexapeptide-38 distinct — the adipogenesis route to volume?
Its distinctive mechanism is soft-tissue volume through adipogenesis (PPARγ) — supporting the subcutaneous fat pad — rather than building collagen or relaxing muscle. That makes it a complementary “volume” partner alongside structural and matrix peptides in a plumping system. Acetyl Hexapeptide-38 is freely water-soluble and dissolves directly in the aqueous phase.
What addition temperature is recommended for Acetyl Hexapeptide-38 (Adifyline) during manufacturing?
Introduce Acetyl Hexapeptide-38 (Adifyline) during the cool-down phase at temperatures below 40°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Adifyline stable in a finished formula?
Acetyl Hexapeptide-38 is most stable at roughly pH 4.5–7.0, suited to serums, lip products and emulsions; confirm the finished-product pH after all actives are incorporated.
Is Acetyl Hexapeptide-38 (Adifyline) compatible with other actives in multi-active cosmetic systems?
Acetyl Hexapeptide-38 (Adifyline) is compatible with standard cosmetic actives at pH 4.5–7.0 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Acetyl Hexapeptide-38 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Acetyl Hexapeptide-38 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 1400634-44-7 and INCI name Acetyl Hexapeptide-38 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Acetyl Hexapeptide-38 (Adifyline) be stored?
Store Acetyl Hexapeptide-38 (Adifyline) sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Acetyl Hexapeptide-38 (Adifyline)?
TCS NEXUS S.L. provides COA (confirming CAS 1400634-44-7 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Acetyl Hexapeptide-38 (Adifyline). Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Acetyl Hexapeptide-38 (Adifyline)?
Sample and bulk quantities for Acetyl Hexapeptide-38 (Adifyline) are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.