Myristoyl Tetrapeptide-12 (CAS 959610-24-3) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. With limited direct water solubility, it requires propylene glycol or ethanol pre-dispersion before aqueous dilution, at pH 4.5–7.0, with incorporation below 40°C in standard emulsion manufacturing protocols.
> Technical Specifications
| Product Name | Myristoyl Tetrapeptide-12 |
|---|---|
| Molecular Structure |  |
| CAS Number | 959610-24-3 |
| Alias / Common Name | Myristoyl Tetrapeptide-12; lash and follicle ECM lipopeptide |
| Molecular Formula | C32H63N7O5 |
| Molecular Weight | 625.9 g/mol |
| INCI Name | Myristoyl Tetrapeptide-12 |
| Peptide Sequence | Myristoyl tetrapeptide — C14 myristoyl-anchored follicle ECM targeting tetrapeptide |
| Functional Class | Synthetic lipopeptide; hair follicle ECM and lash root anchoring active; follicle proliferation and dermal papilla support peptide |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Lipopeptide; limited direct water dispersibility. Pre-disperse in propylene glycol (5–15%) at 40–50°C before adding to the formulation at cool-down below 40°C. |
| pH Stability | Optimal stability at pH 4.5–7.0. Confirm stability in the complete formulation base. |
| Storage | Store sealed below 25°C in a cool, dry location protected from direct light and moisture. Follow SDS and batch COA conditions. |
> Mechanism & Positioning
Myristoyl Tetrapeptide-12 is a synthetic C14 myristoyl lipopeptide designed to support hair follicle ECM architecture and lash root dermal papilla function. Published Myristoyl Tetrapeptide-12 literature discusses upregulation of follicle ECM proteins — collagen IV, laminin and fibronectin — in the connective tissue sheath and basement membrane zone surrounding the hair follicle dermal papilla. Cell-based dermal papilla cell studies document improved ECM protein deposition, maintained cell-matrix adhesion and increased secretion of paracrine growth factors (IGF-1, VEGF) in model follicle papilla systems. Hair follicle anchoring model data also notes reduced premature follicle regression markers (reduced catagen index) and improved dermal papilla size maintenance in organ-culture hair follicle assays, consistent with ECM structural support of the anagen-promoting dermal papilla niche. The myristoyl anchor targets the lipopeptide to follicle outer root sheath and dermal papilla membrane compartments for local ECM support at the follicle anchoring site.
Myristoyl Tetrapeptide-12 builds multi-mechanism lash and scalp density systems with Myristoyl Pentapeptide-17 (keratin shaft synthesis) and Myristoyl Hexapeptide-16 (stem cell niche activation). All three myristoyl lipopeptides can be co-formulated in a shared PG pre-dispersion at combined concentrations up to 0.15% total lipopeptide — confirm combined PG tolerance before scale-up. Contact info@tcspeptides.com with formulation specification.
> Application Concepts
Lash Root Anchoring Serum and Myristoyl ECM Lipopeptide Architecture
Myristoyl Tetrapeptide-12 at 0.005–0.05% requires PG pre-dispersion (5–15 parts PG per 1 part peptide, 40–50°C) before addition to the serum base at cool-down below 40°C. It is appropriate for lash root serums, brow density concentrates and scalp treatment formulations where follicle ECM anchoring support is the primary claim basis. For a comprehensive three-myristoyl lash system, combine Myristoyl Tetrapeptide-12 (follicle ECM anchoring) with Myristoyl Pentapeptide-17 (keratin synthesis) and Myristoyl Hexapeptide-16 (stem cell niche) in a shared PG pre-dispersion for a single-step lipopeptide addition at cool-down.
Follicle ECM Architecture vs Stem Cell Niche — Two Structural Levels of Follicle Support
Hair follicle retention and cycling integrity operates at two structural levels: the stem cell niche in the bulge (Wnt/Shh signalling → anagen initiation, targeted by Myristoyl Hexapeptide-16) and the dermal papilla ECM scaffold (collagen IV/laminin/fibronectin architecture supporting papilla size and paracrine signalling capacity — targeted by Myristoyl Tetrapeptide-12). Stem cell activation without dermal papilla ECM support leads to anagen initiation but reduced follicle cycling endurance (smaller papilla → shorter anagen). Dermal papilla ECM support without stem cell activation maintains papilla structure but does not trigger new anagen cycles. Combining Myristoyl Tetrapeptide-12 and Myristoyl Hexapeptide-16 addresses both structural levels — initiation capacity (stem cell) and maintenance scaffold (papilla ECM) — for comprehensive follicle cycling support.
Premium Lash, Brow Root and Scalp Anchoring Format Applications
Myristoyl Tetrapeptide-12 at 0.005–0.05% is positioned for three precision hair cosmetic segments: lash root ECM support serums (dermal papilla anchoring under lash root — reduces premature lash shedding), brow hair ECM root concentrates (follicle ECM anchoring for thinning brow hair retention) and scalp ECM support treatments (dermal papilla size preservation in miniaturising follicles). For scalp positioning in thinning or androgenetic conditions, combine Myristoyl Tetrapeptide-12 with Acetyl Tetrapeptide-3 (Folixyl) (5α-R / DHT miniaturisation inhibition) and Myristoyl Hexapeptide-16 (Wnt/Shh anagen initiation) for a three-mechanism scalp treatment addressing DHT, papilla ECM and stem cell activation in a single professional concentrate.
> Handling & Formulation Notes
Pre-disperse Myristoyl Tetrapeptide-12 in propylene glycol (5–15 parts PG per 1 part peptide) at 40–50°C with gentle stirring until uniform dispersion is achieved. Add the PG dispersion to the formulation at cool-down below 40°C. Avoid direct addition of undispersed powder to hot aqueous phases. Avoid prolonged heating above 45°C to protect the myristoyl amide bond.
Confirm stability of Myristoyl Tetrapeptide-12 in the complete lash or scalp formulation at 40°C/75% RH for 12 weeks before scale-up. Monitor lipopeptide integrity by HPLC when formulating at pH outside 4.5–7.0. Follow SDS and batch COA for storage and handling; confirm shelf life for the specific batch. EDTA at ≤0.1% is compatible as a chelating buffer in emulsion systems; avoid strong oxidising agents (H₂O₂ ≥1%, benzoyl peroxide) and high-pH bases above pH 8.0.
> Supply & Documentation
Myristoyl Tetrapeptide-12 (CAS 959610-24-3) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Myristoyl Tetrapeptide-12 is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Myristoyl Tetrapeptide-12?
Myristoyl Tetrapeptide-12 (CAS 959610-24-3) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Myristoyl Tetrapeptide-12 is positioned as a lipopeptide targeting keratinocyte proliferation and scalp epidermis renewal — evaluated in leave-on scalp serums for follicle density and scalp health applications. TCS NEXUS S.L. supplies Myristoyl Tetrapeptide-12 as a B2B active for formulators developing targeted scalp and hair-density treatments.
What is the CAS number for Myristoyl Tetrapeptide-12?
The CAS number for Myristoyl Tetrapeptide-12 is 959610-24-3. The INCI name for cosmetic regulatory documentation and CPNP notification is Myristoyl Tetrapeptide-12; confirm CAS 959610-24-3 and INCI identity against the batch COA when building product files.
How does Myristoyl Tetrapeptide-12 support lash roots — what is its follicle-ECM mechanism?
Myristoyl Tetrapeptide-12 is a C14 myristoyl-anchored tetrapeptide positioned to support the extracellular matrix around the hair follicle and lash root, reinforcing the anchoring of the shaft and supporting the dermal papilla that drives growth. It is used in lash- and brow-conditioning products for the appearance of stronger, denser lashes. The myristoyl chain provides delivery lipophilicity.
What use level of Myristoyl Tetrapeptide-12 is typical, and how should it be evaluated?
There is no one-size-fits-all dose: establish the use level conservatively for your base and claim; it is usually a trade solution, so confirm your dosing basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Myristoyl Tetrapeptide-12 in a lash serum?
Myristoyl Tetrapeptide-12 (follicle-ECM anchoring) combines with the lash-conditioning duo Myristoyl Pentapeptide-17 (keratin) and Myristoyl Hexapeptide-16 (stem-cell niche) and with Biotinoyl Tripeptide-1, panthenol and hyaluronic acid. As a lipopeptide it needs pre-dispersion; confirm clarity and pH in the finished serum base.
What makes Myristoyl Tetrapeptide-12 distinct among lash peptides?
Its distinctive focus is the follicle extracellular matrix and lash-root anchoring — reinforcing where the lash attaches and supporting the dermal papilla — which complements the keratin-building (Myristoyl Pentapeptide-17) and stem-cell (Myristoyl Hexapeptide-16) lash peptides rather than duplicating them. As a lipopeptide it has limited water solubility and is pre-dispersed before use.
What addition temperature is recommended for Myristoyl Tetrapeptide-12 during manufacturing?
Introduce Myristoyl Tetrapeptide-12 during the cool-down phase at temperatures below 40°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Myristoyl Tetrapeptide-12 stable in a finished formula?
Myristoyl Tetrapeptide-12 is most stable at roughly pH 4.5–7.0; confirm the finished-product pH after all actives are incorporated and evaluate combined stability in the complete serum base.
Is Myristoyl Tetrapeptide-12 compatible with other actives in multi-active cosmetic systems?
Myristoyl Tetrapeptide-12 is compatible with standard cosmetic actives at pH 4.5–7.0 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Myristoyl Tetrapeptide-12 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Myristoyl Tetrapeptide-12 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 959610-24-3 and INCI name Myristoyl Tetrapeptide-12 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Myristoyl Tetrapeptide-12 be stored?
Store Myristoyl Tetrapeptide-12 sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Myristoyl Tetrapeptide-12?
TCS NEXUS S.L. provides COA (confirming CAS 959610-24-3 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Myristoyl Tetrapeptide-12. Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Myristoyl Tetrapeptide-12?
Sample and bulk quantities for Myristoyl Tetrapeptide-12 are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.