Hexapeptide-9 (Collaxyl) (CAS 885024-94-2) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. A freely water-soluble peptide, it dissolves directly in aqueous concentrates without co-solvents at pH 5.0–7.5, with cool-down addition below 45°C recommended in standard serum and leave-on manufacturing protocols.
> Technical Specifications
| Product Name | Hexapeptide-9 (Collaxyl) |
|---|---|
| Molecular Structure |  |
| CAS Number | 885024-94-2 |
| Alias / Common Name | Hexapeptide-9; Gly-Pro-Gln-Gly-Pro-Gln |
| Molecular Formula | C24H38N8O9 |
| Molecular Weight | 582.6 g/mol |
| INCI Name | Hexapeptide-9 |
| Peptide Sequence | Gly-Pro-Gln-Gly-Pro-Gln — collagen proline-rich domain repeat biomimetic (ECM synthesis modulator) |
| Functional Class | Synthetic hexapeptide; collagen proline-rich repeat biomimetic; collagen I/IV and fibronectin synthesis modulator |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Freely water-soluble; dissolve in deionised water or aqueous phase at ambient temperature; no co-solvent required |
| pH Stability | Optimal stability at pH 5.0–7.5; confirm in the complete formulation after all actives |
| Storage | Store sealed below 25°C in cool, dry, light-protected conditions; follow batch COA and SDS |
> Mechanism & Positioning
Hexapeptide-9 (Collaxyl, Gly-Pro-Gln-Gly-Pro-Gln, CAS 885024-94-2) is a synthetic collagen proline-rich domain repeat hexapeptide based on the (Gly-Pro-X)n triplet repeat sequence fundamental to the triple helix structure of fibrillar collagens — with Gly-Pro-Gln representing a collagen domain-derived hexapeptide designed to interact with dermal fibroblast collagen-receptor and ECM synthesis machinery. Published Hexapeptide-9 (Collaxyl) literature discusses interaction with discoidin domain receptor (DDR) collagen-receptor pathways and associated upregulation of collagen type I and type IV synthesis in dermal fibroblast cell systems. Cell-based fibroblast studies document pro-collagen I output modulation alongside fibronectin deposition and basement membrane component synthesis, consistent with the collagen proline-repeat biomimetic pharmacophore. ECM model data also notes laminin-5 pathway interaction and dermal-epidermal junction (DEJ) collagen IV assembly modulation in three-dimensional skin model systems, supporting the positioning of Hexapeptide-9 for multi-collagen-type serum and anti-age emulsion formulation concepts.
Based on available in vitro data, Hexapeptide-9 (Collaxyl) is positioned for collagen-synthesis serum, basement-membrane support concentrate and multi-active matrix-care emulsion concepts where collagen I/IV and fibronectin pathway modulation are the formulation directions. The collagen proline-repeat biomimetic mechanism is independent from and complementary to the fibronectin-receptor TGF-β1 signalling of Matrixyl, enabling multi-pathway collagen synthesis architecture in a premium anti-age serum concentrate.
> Application Concepts
Collagen-Synthesis Serum and Anti-Age Concentrate Architecture
Hexapeptide-9 (Collaxyl) dissolves freely in deionised water, glycerin–water and buffered aqueous serum bases at 10–1000 ppm without co-solvent. Introduce during the cool-down phase below 45°C; standard aqueous serum and emulsion manufacturing protocols are compatible. For multi-pathway collagen positioning, combine Hexapeptide-9 (collagen proline-repeat DDR pathway) with Matrixyl (fibronectin receptor TGF-β1 KTTKS-GQPR) and GHK-Cu (LOX crosslinking copper) in the same aqueous serum base. Confirm pH alignment (5.0–7.5) and peptide assay retention via HPLC at 40°C/75% RH before scale-up.
Basement Membrane and DEJ-Support Serum Formulation
The collagen IV and laminin pathway activity of Hexapeptide-9 (Collaxyl) makes it particularly relevant for formulations targeting dermal-epidermal junction (DEJ) integrity — the basement membrane collagen IV network is degraded in photoaged and chronologically aged skin, contributing to flattening of rete ridges and reduced epidermal-dermal mechanical cohesion. At 10–1000 ppm alongside Acetyl Tetrapeptide-9 (Dermican) (lumican synthesis, collagen fibril diameter) and Tripeptide-10 Citrulline (Decorinyl) (decorin/fibrillin fibril organisation), a three-active basement membrane and collagen architecture serum addresses multiple structural ECM targets. All three are water-soluble and pH-compatible at 5.0–7.5. Confirm combined stability and assay retention before scale-up.
Multi-Collagen-Type Premium Age-Care Concentrate
A premium anti-age concentrate combining Hexapeptide-9 (collagen I/IV synthesis), Matrixyl (TGF-β1/fibronectin collagen I/III), GHK-Cu (LOX crosslinking) and Tripeptide-10 Citrulline (collagen fibril diameter/decorin) addresses four distinct structural ECM pathways — from fibrillar collagen synthesis to basement membrane assembly, LOX crosslink maturation and collagen fibril organisation. All four are water-soluble and pH-compatible in the same aqueous serum base at pH 5.0–7.5. Each active is evaluated at 10–1000 ppm; combined use levels stay within standard formulation economics for premium SKU positioning. Confirm combined peptide assay retention, pH and stability via accelerated testing at 40°C/75% RH before committing to production scale.
> Handling & Formulation Notes
Dissolve Hexapeptide-9 (Collaxyl) in deionised water or the aqueous phase at ambient temperature at 10–1000 ppm without co-solvent. Freely water-soluble and stable at standard processing temperatures. Introduce during the cool-down phase below 45°C. Maintain formulation pH within 5.0–7.5.
Evaluate compatibility with preservative systems and chelating agents at typical cosmetic concentrations. Confirm peptide assay retention by HPLC after accelerated stability at 40°C/75% RH before production. Standard manufacturing protocols for aqueous serum and emulsion systems are compatible with Hexapeptide-9 addition.
> Supply & Documentation
Hexapeptide-9 (Collaxyl) (CAS 885024-94-2) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Hexapeptide-9 (Collaxyl) is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Hexapeptide-9 (Collaxyl)?
Hexapeptide-9 (Collaxyl) (CAS 885024-94-2) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Hexapeptide-9 (Collaxyl) is positioned as a type III collagen-stimulating hexapeptide — evaluated in anti-ageing and skin-firmness serums targeting the preferential loss of type III collagen (“baby collagen”) that occurs in the upper dermis with chronological ageing and UV damage. TCS NEXUS S.L. supplies Hexapeptide-9 as a B2B active for anti-ageing formulation specialists.
What is the CAS number for Hexapeptide-9 (Collaxyl)?
The CAS number for Hexapeptide-9 (Collaxyl) is 885024-94-2. The INCI name for cosmetic regulatory documentation and CPNP notification is Hexapeptide-9; confirm CAS 885024-94-2 and INCI identity against the batch COA when building product files.
How does Collaxyl support collagen — what is the proline-rich repeat mechanism?
Hexapeptide-9 (Collaxyl) has the sequence Gly-Pro-Gln-Gly-Pro-Gln, a biomimetic of the proline-rich repeat motif found in collagen. It is described as stimulating synthesis of collagen types I and IV and of fibronectin and improving keratinocyte cohesion, positioning it for firmness, density and smoothing claim directions in age-care formulas.
What use level of Collaxyl is typical, and how should it be evaluated?
Rather than quoting one fixed figure, evaluate the use level conservatively for your base and claim; Collaxyl is often a trade solution, so confirm your dosing basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Collaxyl in a matrix-density system?
Collaxyl stimulates collagen I/IV and fibronectin, so it layers with other synthesis and organisation peptides — Matrixyl, Palmitoyl Tripeptide-5 and Decorinyl — and with niacinamide and hydrators. It is water-soluble; confirm combined stability and pH in the finished base.
What makes Hexapeptide-9 distinct — the collagen I/IV and fibronectin focus?
Its distinctive feature is the collagen proline-rich repeat design and its reported action on both collagen I and collagen IV plus fibronectin and cell cohesion — collagen IV and fibronectin being basement-membrane and adhesion components, not just dermal collagen I. That broad matrix-and-adhesion focus differentiates it from single-target matrikines. Hexapeptide-9 is freely water-soluble.
What addition temperature is recommended for Hexapeptide-9 (Collaxyl) during manufacturing?
Introduce Hexapeptide-9 (Collaxyl) during the cool-down phase at temperatures below 45°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Collaxyl stable in a finished formula?
Hexapeptide-9 is most stable at roughly pH 4.5–7.0; confirm the finished-product pH after all actives are incorporated and evaluate combined stability with low-pH actives such as ascorbic acid.
Is Hexapeptide-9 (Collaxyl) compatible with other actives in multi-active cosmetic systems?
Hexapeptide-9 (Collaxyl) is compatible with standard cosmetic actives at pH 5.0–7.5 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Hexapeptide-9 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Hexapeptide-9 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 885024-94-2 and INCI name Hexapeptide-9 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Hexapeptide-9 (Collaxyl) be stored?
Store Hexapeptide-9 (Collaxyl) sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Hexapeptide-9 (Collaxyl)?
TCS NEXUS S.L. provides COA (confirming CAS 885024-94-2 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Hexapeptide-9 (Collaxyl). Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Hexapeptide-9 (Collaxyl)?
Sample and bulk quantities for Hexapeptide-9 (Collaxyl) are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.