Hexapeptide-11 (Filmexel) (CAS 161258-30-6) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. A freely water-soluble peptide, it dissolves directly in aqueous concentrates without co-solvents at pH 5.0–7.5, with cool-down addition below 45°C recommended in standard serum and leave-on manufacturing protocols.
> Technical Specifications
| Product Name | Hexapeptide-11 (Filmexel) |
|---|---|
| Molecular Structure |  |
| CAS Number | 161258-30-6 |
| Alias / Common Name | Hexapeptide-11; Peptamide 6; Phe-Val-Ala-Pro-Phe-Pro |
| Molecular Formula | C36H48N6O7 |
| Molecular Weight | 676.8 g/mol |
| INCI Name | Hexapeptide-11 |
| Peptide Sequence | Phe-Val-Ala-Pro-Phe-Pro — FVAPFP, Saccharomyces cerevisiae protein-derived hexapeptide (ECM/fibronectin synthesis; EGFR pathway) |
| Functional Class | Yeast-derived hexapeptide; EGFR/fibronectin ECM pathway modulator; skin-firming active; dermal density active |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Freely water-soluble; dissolve in deionised water or aqueous phase at ambient temperature; no co-solvent required |
| pH Stability | Optimal stability at pH 5.0–7.5; confirm in the complete formulation after all actives |
| Storage | Store sealed below 25°C in cool, dry, light-protected conditions; follow batch COA and SDS |
> Mechanism & Positioning
Hexapeptide-11 (Filmexel, Phe-Val-Ala-Pro-Phe-Pro, CAS 161258-30-6) is a proline-rich hexapeptide derived from the protein hydrolysate of Saccharomyces cerevisiae (baker’s yeast) — specifically from the Cytochrome b5 protein sequence — designed to modulate ECM fibronectin deposition and dermal fibroblast proliferation-related signalling pathways. Published Hexapeptide-11 literature discusses interaction with EGFR (epidermal growth factor receptor)-related cell vitality signalling and fibronectin assembly cascades in dermal fibroblast systems: the Pro-Phe-Pro C-terminal tripeptide element has been discussed as an SH3 domain-binding motif that may interact with signalling scaffold proteins associated with cytoskeletal organisation and fibronectin deposition. Cell-based dermal fibroblast studies document fibronectin production modulation and fibroblast viability-related pathway activity, with associated dermal density and skin tightening effects in three-dimensional fibroblast ECM assay systems. Firming model data also notes cell proliferation-associated pathway modulation and extracellular matrix reorganisation effects at evaluated hexapeptide concentrations.
Based on available in vitro data, Hexapeptide-11 (Filmexel) is positioned for skin-firming serum, anti-sag concentrate and advanced age-care formulation concepts where fibronectin ECM deposition and dermal density are the primary mechanistic directions. The yeast-derived EGFR/fibronectin mechanism complements the TGF-β1 collagen synthesis pathway of Matrixyl and the LOX crosslinking of GHK-Cu, providing independent fibronectin-ECM organisation pathway activity for multi-active firming serum architecture.
> Application Concepts
Skin-Firming Serum and Anti-Sag Concentrate Architecture
Hexapeptide-11 (Filmexel) dissolves freely in deionised water and aqueous serum bases at 0.5–2.0% (w/w) without co-solvent. Introduce during the cool-down phase below 45°C; standard aqueous serum and emulsion protocols are compatible. Note the relatively higher use concentration (0.5–2.0% vs the 10–1000 ppm range of signal peptides) — typical for yeast protein-derived hexapeptides where mass-based dosing is required for ECM fibroblast pathway activity. For firming serum, combine with Matrixyl (TGF-β1 collagen I/III), GHK-Cu (LOX crosslinking) and niacinamide (barrier/anti-sag) at pH 5.0–7.0. Confirm clarity and combined stability at 40°C/75% RH before scale-up.
Dermal Density and Fibronectin ECM-Support Formulations
Hexapeptide-11’s fibronectin assembly and cell vitality-signalling activity positions it for anti-sag concentrates targeting loss of dermal density — a primary contributor to facial volume loss and jowl formation in aged skin. At 0.5–2.0% in an emulsion or rich serum base, Hexapeptide-11 contributes ECM fibronectin network organisation alongside collagen-synthesis actives. Combine with Acetyl Hexapeptide-38 (Adifyline) for complementary hypodermal adipogenesis/volumizing positioning alongside dermal fibronectin architecture — the combination targets both dermal density (Filmexel) and hypodermal fat compartment volume (Adifyline). Confirm combined pH (5.0–7.0) and stability before production scale-up.
Multi-Active Premium Firming Concentrate Formats
Premium firming concentrate architecture with Hexapeptide-11 (0.5–2.0%) + Matrixyl (10–1000 ppm TGF-β1 collagen synthesis) + GHK-Cu (10–1000 ppm LOX crosslinking) + Tripeptide-10 Citrulline (10–100 ppm decorin-fibril organisation) provides a comprehensive four-pathway firming system in a single aqueous serum concentrate. All four actives are water-soluble and pH-compatible at 5.0–7.5. The higher Hexapeptide-11 use level (0.5–2.0%) may affect formulation transparency in clear serum formats — evaluate clarity at the target concentration and consider lightweight polymer thickener systems for gel consistency. Confirm combined peptide assay retention and stability at 40°C/75% RH before production scale-up.
> Handling & Formulation Notes
Dissolve Hexapeptide-11 (Filmexel) in deionised water or the aqueous phase at ambient temperature at 0.5–2.0% (w/w) without co-solvent. Freely water-soluble at these concentrations. Introduce during the cool-down phase below 45°C. Maintain formulation pH within 5.0–7.5. At higher use concentrations (≥1.5%), evaluate batch viscosity impact on serum rheology.
Evaluate compatibility with standard preservative systems and chelating agents at typical cosmetic concentrations. Confirm peptide assay retention by HPLC and evaluate appearance/clarity in the specific formulation base after accelerated stability at 40°C/75% RH before production scale-up.
> Supply & Documentation
Hexapeptide-11 (Filmexel) (CAS 161258-30-6) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Hexapeptide-11 (Filmexel) is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Hexapeptide-11 (Filmexel)?
Hexapeptide-11 (Filmexel) (CAS 161258-30-6) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Hexapeptide-11 (Filmexel) is positioned as a yeast-derived biopolymer-forming hexapeptide that creates a viscoelastic film on the skin surface — evaluated in anti-ageing serums and primers targeting immediate optical skin-smoothing, fine-line blurring and texture improvement as a film-former and structural peptide. TCS NEXUS S.L. supplies Hexapeptide-11 as a B2B active for formulators developing skin-refinement and anti-ageing leave-on products.
What is the CAS number for Hexapeptide-11 (Filmexel)?
The CAS number for Hexapeptide-11 (Filmexel) is 161258-30-6. The INCI name for cosmetic regulatory documentation and CPNP notification is Hexapeptide-11; confirm CAS 161258-30-6 and INCI identity against the batch COA when building product files.
How does Hexapeptide-11 support dermal density — what is its yeast-derived mechanism?
Hexapeptide-11 (Filmexel; also known as Peptamide 6) is the sequence Phe-Val-Ala-Pro-Phe-Pro (FVAPFP), derived from a Saccharomyces cerevisiae protein. It is described as supporting fibroblast activity and extracellular-matrix and fibronectin synthesis for dermal-density and firmness positioning, and in film-forming “second-skin” systems it also contributes a soothing, smoothing feel.
What use level of Hexapeptide-11 is typical, and how should it be evaluated?
Because the effective level shifts with formulation and claim, build it up conservatively from your own evaluation instead of fixing on one number; Hexapeptide-11 is often a trade solution, so confirm your dosing basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Hexapeptide-11 in a density and comfort system?
Hexapeptide-11 layers with matrix-synthesis peptides such as Matrixyl and Palmitoyl Tripeptide-5, with soothing actives, and with film-forming polysaccharides for “second-skin” comfort systems, plus niacinamide. It is water-soluble; confirm combined stability and pH in the finished base.
What makes Hexapeptide-11 distinct — its yeast origin and dual role?
Two things set Hexapeptide-11 apart: its origin as a Saccharomyces cerevisiae yeast-protein-derived sequence (FVAPFP, also called Peptamide 6), and its dual positioning — supporting ECM and fibronectin for dermal density while also being used in soothing, film-forming “second-skin” concepts. It is freely water-soluble and dissolves directly in the aqueous phase.
What addition temperature is recommended for Hexapeptide-11 (Filmexel) during manufacturing?
Introduce Hexapeptide-11 (Filmexel) during the cool-down phase at temperatures below 45°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Hexapeptide-11 stable in a finished formula?
Hexapeptide-11 is most stable at roughly pH 4.5–7.0; confirm the finished-product pH after all actives are incorporated and evaluate combined stability with low-pH actives such as ascorbic acid.
Is Hexapeptide-11 (Filmexel) compatible with other actives in multi-active cosmetic systems?
Hexapeptide-11 (Filmexel) is compatible with standard cosmetic actives at pH 5.0–7.5 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Hexapeptide-11 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Hexapeptide-11 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 161258-30-6 and INCI name Hexapeptide-11 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Hexapeptide-11 (Filmexel) be stored?
Store Hexapeptide-11 (Filmexel) sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Hexapeptide-11 (Filmexel)?
TCS NEXUS S.L. provides COA (confirming CAS 161258-30-6 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Hexapeptide-11 (Filmexel). Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Hexapeptide-11 (Filmexel)?
Sample and bulk quantities for Hexapeptide-11 (Filmexel) are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.