Acetyl Tetrapeptide-11 (Syniorage) (CAS 928006-88-6) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. A freely water-soluble peptide, it dissolves directly in aqueous concentrates without co-solvents at pH 5.0–7.5, with cool-down addition below 45°C recommended in standard serum and leave-on manufacturing protocols.
> Technical Specifications
| Product Name | Acetyl Tetrapeptide-11 (Syniorage) |
|---|---|
| Molecular Structure |  |
| CAS Number | 928006-88-6 |
| Alias / Common Name | Acetyl Tetrapeptide-11; Ac-Pro-Pro-Tyr-Leu |
| Molecular Formula | C27H38N4O7 |
| Molecular Weight | 530.6 g/mol |
| INCI Name | Acetyl Tetrapeptide-11 |
| Peptide Sequence | Ac-Pro-Pro-Tyr-Leu-OH — Syniorage (syndecan-1 / DEJ integrity signalling) |
| Functional Class | Synthetic tetrapeptide; syndecan-1 proteoglycan synthesis modulator; DEJ integrity active; firming peptide |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Freely water-soluble; dissolve in deionised water or aqueous phase at ambient temperature; no co-solvent required |
| pH Stability | Optimal stability at pH 5.0–7.5; confirm in the complete formulation after all actives |
| Storage | Store sealed below 25°C in cool, dry, light-protected conditions; follow batch COA and SDS |
> Mechanism & Positioning
Acetyl Tetrapeptide-11 (Syniorage, Ac-Pro-Pro-Tyr-Leu, CAS 928006-88-6) is a proline-rich synthetic N-acetylated tetrapeptide designed to modulate syndecan-1 (CD138) proteoglycan expression in dermal fibroblasts, targeting the transmembrane heparan sulfate proteoglycan that mediates dermal-epidermal junction (DEJ) cell adhesion and ECM signalling. Published Acetyl Tetrapeptide-11 literature discusses syndecan-1 as a transmembrane HSPG that acts as a co-receptor for growth factors (FGF-2, HGF), ECM fibronectin, collagen and laminin — modulating integrin-mediated adhesion, keratinocyte-fibroblast signalling at the DEJ and ECM remodelling coordination. Cell-based dermal fibroblast studies document syndecan-1 expression modulation and associated changes in DEJ-related adhesion molecule output and growth factor receptor co-receptor signalling. DEJ integrity model data also notes type VII collagen and anchoring fibril pathway modulation in skin model systems, supporting the firming and DEJ-integrity positioning of Acetyl Tetrapeptide-11 in premium age-care formulation concepts.
Based on available in vitro data, Acetyl Tetrapeptide-11 (Syniorage) is positioned for skin-firming serum, DEJ-integrity concentrate and premium age-care emulsion concepts where syndecan-1 pathway-mediated DEJ adhesion and ECM signalling are the mechanistic targets. The syndecan-1 transmembrane HSPG mechanism is distinct from and complementary to the SLRP lumican pathway of Acetyl Tetrapeptide-9 (Dermican), enabling two-mechanism DEJ-support architecture in the same aqueous serum, further combined with Hexapeptide-9 for collagen IV basement membrane coverage.
> Application Concepts
DEJ-Integrity and Syndecan-1 Firming Serum Architecture
Acetyl Tetrapeptide-11 (Syniorage) dissolves freely in deionised water and aqueous serum bases at 10–100 ppm without co-solvent. Introduce during the cool-down phase below 45°C. For DEJ-integrity firming serum positioning, combine Syniorage (syndecan-1 HSPG co-receptor signalling) with Acetyl Tetrapeptide-9 Dermican (lumican SLRP / collagen XVII) and Hexapeptide-9 Collaxyl (collagen IV basement membrane) in the same aqueous concentrate — three independent DEJ-architecture peptides, all water-soluble and pH-compatible at 5.0–7.5. Add Matrixyl for TGF-β1 fibronectin-receptor collagen I/III synthesis support. Confirm combined assay retention and stability at 40°C/75% RH before scale-up.
Syndecan-1 as a DEJ Co-Receptor: Formulation Rationale
Syndecan-1 serves as a co-receptor for FGF-2, HGF and TGF-β at the DEJ — its downregulation with aging reduces keratinocyte sensitivity to fibroblast-derived growth factors and impairs the bidirectional signalling that maintains epidermal renewal and dermal matrix production. Acetyl Tetrapeptide-11 (Syniorage) by upregulating syndecan-1 expression potentially restores growth factor co-receptor signalling at the DEJ, supporting epidermal regeneration pathways alongside DEJ adhesion. For a premium comprehensive DEJ and regeneration serum, combine Syniorage with Dermican (collagen XVII hemidesmosomes) and matrix synthesis actives. All are water-soluble and pH-compatible. Confirm combined DEJ-related pathway activity in an appropriate assay before production.
Multi-Active DEJ Support in Premium Firming Concentrates
At 10–100 ppm, Acetyl Tetrapeptide-11 (Syniorage) is cost-efficient for inclusion in premium firming concentrates targeting multiple DEJ structural components simultaneously. Combined with Dermican (collagen XVII/lumican), Hexapeptide-9 (collagen IV), Matrixyl (TGF-β1 fibronectin collagen I/III) and GHK-Cu (LOX crosslinking), a five-peptide multi-pathway firming concentrate addresses DEJ integrity, ECM architecture, collagen synthesis and crosslinking in a single serum formulation. All five actives are freely water-soluble, stable at pH 5.0–7.5 and added during cool-down below 45°C. Confirm combined clarity, pH and peptide assay retention via HPLC at 40°C/75% RH before production.
> Handling & Formulation Notes
Dissolve Acetyl Tetrapeptide-11 (Syniorage) in deionised water or the aqueous phase at ambient temperature at 10–100 ppm without co-solvent. Freely water-soluble at evaluation concentrations. Introduce during cool-down below 45°C. Maintain formulation pH within 5.0–7.5.
Evaluate compatibility with preservative systems and chelating agents. The proline-rich sequence (Pro-Pro) provides peptidase resistance; confirm assay retention by HPLC after accelerated stability at 40°C/75% RH before production scale-up.
> Supply & Documentation
Acetyl Tetrapeptide-11 (Syniorage) (CAS 928006-88-6) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Acetyl Tetrapeptide-11 (Syniorage) is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Acetyl Tetrapeptide-11 (Syniorage)?
Acetyl Tetrapeptide-11 (Syniorage) (CAS 928006-88-6) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Acetyl Tetrapeptide-11 (Syniorage) is positioned as a proteoglycan-stimulating peptide that improves dermal glycosaminoglycan (GAG) content — evaluated in anti-ageing serums targeting the decline in hyaluronic acid, chondroitin sulphate and heparan sulphate that contributes to loss of dermal hydration, turgidity and cushioning with age. TCS NEXUS S.L. supplies Acetyl Tetrapeptide-11 as a B2B active for anti-ageing formulation specialists.
What is the CAS number for Acetyl Tetrapeptide-11 (Syniorage)?
The CAS number for Acetyl Tetrapeptide-11 (Syniorage) is 928006-88-6. The INCI name for cosmetic regulatory documentation and CPNP notification is Acetyl Tetrapeptide-11; confirm CAS 928006-88-6 and INCI identity against the batch COA when building product files.
How does Syniorage support firmness — what is the syndecan-1 / DEJ mechanism?
Acetyl Tetrapeptide-11 (Syniorage) is the acetylated tetrapeptide Pro-Pro-Tyr-Leu (PPYL). It is described as boosting synthesis of syndecan-1, a proteoglycan that helps hold keratinocytes together and reinforce the dermal-epidermal junction (DEJ). A stronger DEJ and better epidermal cohesion relate to firmness and resilience, which is its claim positioning.
What use level of Syniorage is typical, and how should it be evaluated?
Establish the use level conservatively for your base and claim rather than to a fixed figure; Syniorage is usually a trade solution, so confirm whether you dose on a pure-peptide or solution basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Syniorage in a firmness and cohesion system?
Syniorage reinforces the DEJ, so it complements collagen-stimulating peptides (Matrixyl, Palmitoyl Tripeptide-5), fibril-organising Decorinyl and structural Acetyl Tetrapeptide-9 (Dermican), plus niacinamide for barrier support. It is water-soluble; confirm combined stability and pH in the finished base.
What makes Acetyl Tetrapeptide-11 distinct — the syndecan-1 / DEJ target?
Its distinctive target is syndecan-1 and the dermal-epidermal junction rather than dermal collagen directly: strengthening keratinocyte cohesion and the DEJ addresses the junction where ageing weakens skin attachment. That places it alongside — not in competition with — collagen-synthesis peptides. Acetyl Tetrapeptide-11 is freely water-soluble.
What addition temperature is recommended for Acetyl Tetrapeptide-11 (Syniorage) during manufacturing?
Introduce Acetyl Tetrapeptide-11 (Syniorage) during the cool-down phase at temperatures below 45°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Syniorage stable in a finished formula?
Acetyl Tetrapeptide-11 is most stable at roughly pH 4.5–7.0; confirm the finished-product pH after all actives are incorporated and evaluate combined stability with low-pH actives such as ascorbic acid.
Is Acetyl Tetrapeptide-11 (Syniorage) compatible with other actives in multi-active cosmetic systems?
Acetyl Tetrapeptide-11 (Syniorage) is compatible with standard cosmetic actives at pH 5.0–7.5 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Acetyl Tetrapeptide-11 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Acetyl Tetrapeptide-11 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 928006-88-6 and INCI name Acetyl Tetrapeptide-11 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Acetyl Tetrapeptide-11 (Syniorage) be stored?
Store Acetyl Tetrapeptide-11 (Syniorage) sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Acetyl Tetrapeptide-11 (Syniorage)?
TCS NEXUS S.L. provides COA (confirming CAS 928006-88-6 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Acetyl Tetrapeptide-11 (Syniorage). Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Acetyl Tetrapeptide-11 (Syniorage)?
Sample and bulk quantities for Acetyl Tetrapeptide-11 (Syniorage) are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.