Acetyl Pentapeptide-1 (CAS 97530-32-0) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. A freely water-soluble peptide, it dissolves directly in aqueous concentrates without co-solvents at pH 5.0–7.5, with cool-down addition below 45°C recommended in standard serum and leave-on manufacturing protocols.
> Technical Specifications
| Product Name | Acetyl Pentapeptide-1 |
|---|---|
| Molecular Structure |  |
| CAS Number | 97530-32-0 |
| Alias / Common Name | Acetyl Pentapeptide-1 |
| Molecular Formula | C32H51N9O10 |
| Molecular Weight | 721.8 g/mol |
| INCI Name | Acetyl Pentapeptide-1 |
| Functional Class | Synthetic N-acetylated pentapeptide; matrix-synthesis supporting active; skin-firming peptide |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Freely water-soluble; dissolve in deionised water or aqueous phase at ambient temperature; no co-solvent required |
| pH Stability | Optimal stability at pH 5.0–7.5; confirm in the complete formulation after all actives |
| Storage | Store sealed below 25°C in cool, dry, light-protected conditions; follow batch COA and SDS |
> Mechanism & Positioning
Acetyl Pentapeptide-1 (CAS 97530-32-0) is a synthetic N-acetylated pentapeptide designed for skin matrix-synthesis support and firming applications in aqueous serum and emulsion formulation systems. Published Acetyl Pentapeptide-1 literature discusses matrix signalling activity in dermal fibroblast and keratinocyte systems through receptor-mediated pathways associated with skin structural protein synthesis and ECM remodelling. Cell-based dermal fibroblast studies document pro-collagen synthesis pathway modulation and associated ECM component deposition, consistent with N-acetylated pentapeptide matrix-signalling pharmacology. ECM support model data also notes effects on structural matrix deposition and fibroblast signalling-pathway activity in in vitro skin model systems at evaluation concentrations of 10–1000 ppm. The N-terminal acetyl modification provides aminopeptidase resistance, potentially supporting peptide stability in the biological and formulation environment. TCS NEXUS S.L. supplies Acetyl Pentapeptide-1 at ≥98% HPLC purity (CAS 97530-32-0) for B2B cosmetic formulation project evaluation; contact info@tcspeptides.com for batch COA and TDS documentation.
Based on available in vitro data, Acetyl Pentapeptide-1 is positioned for matrix-care serum, firming concentrate and advanced age-care formulation concepts where peptide-mediated ECM signalling support is the primary direction. Evaluate Acetyl Pentapeptide-1 in combination with established matrix-synthesis actives such as Matrixyl (Palmitoyl Pentapeptide-4/3) for TGF-β1 collagen I/III pathway coverage and GHK-Cu for LOX-pathway collagen crosslinking support. Contact info@tcspeptides.com with project specification for concentration-range and combination evaluation guidance.
> Application Concepts
Matrix-Care Serum and Firming Concentrate Architecture
Acetyl Pentapeptide-1 dissolves freely in deionised water and aqueous serum bases at 10–1000 ppm without co-solvent or special handling requirements. Introduce during the cool-down phase below 45°C; standard aqueous serum and emulsion manufacturing protocols are fully compatible. For matrix-care positioning, combine with Matrixyl (TGF-β1 collagen synthesis) and GHK-Cu (LOX crosslinking copper) in the same aqueous concentrate — all three are water-soluble, stable at pH 5.0–7.5 and added at cool-down below 45°C. Confirm pH alignment and peptide assay retention by HPLC at 40°C/75% RH before committing to production scale.
N-Acetyl Pentapeptide Stability and Formulation Characteristics
The N-terminal acetyl modification of Acetyl Pentapeptide-1 (CAS 97530-32-0) provides resistance to N-terminal aminopeptidase degradation — relevant to both in vitro stability in the formulation and in situ stability at the skin surface and in the dermal environment. The acetyl group also reduces the positive charge contribution of the N-terminal primary amine, potentially affecting interaction with anionic polymers (carbomers, hyaluronic acid) in serum bases. Evaluate at 10–1000 ppm in the specific formulation base and confirm clarity, pH and peptide assay retention before scale-up. Compare with other N-acetylated matrix peptides such as Acetyl Tetrapeptide-9 (Dermican) and Acetyl Tetrapeptide-11 (Syniorage) in the same formulation base for complementary ECM-pathway coverage.
Premium Anti-Age Concentrate: Multi-Peptide ECM Architecture
Acetyl Pentapeptide-1 can be evaluated as part of a multi-peptide ECM architecture in premium anti-age concentrates targeting multiple matrix signalling pathways simultaneously. At 10–1000 ppm alongside Matrixyl (fibronectin receptor TGF-β1), GHK-Cu (LOX copper), Dermican (lumican/collagen XVII) and Hexapeptide-9 (collagen IV), a comprehensive multi-pathway ECM serum addresses collagen I/III synthesis, LOX crosslinking, DEJ collagen XVII, collagen fibril organisation and basement membrane collagen IV. All are water-soluble and pH-compatible at 5.0–7.5 in the same aqueous base. Confirm combined stability, clarity and peptide assay retention via HPLC after accelerated testing at 40°C/75% RH before production scale-up.
> Handling & Formulation Notes
Dissolve Acetyl Pentapeptide-1 in deionised water or the aqueous phase at ambient temperature at 10–1000 ppm without co-solvent. Freely water-soluble and stable at standard processing temperatures. Introduce during the cool-down phase below 45°C. Maintain formulation pH within 5.0–7.5.
Evaluate compatibility with preservative systems and chelating agents at typical cosmetic concentrations. Confirm peptide assay retention by HPLC after accelerated stability at 40°C/75% RH before production. Contact info@tcspeptides.com for combination evaluation data.
> Supply & Documentation
Acetyl Pentapeptide-1 (CAS 97530-32-0) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Acetyl Pentapeptide-1 is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Acetyl Pentapeptide-1?
Acetyl Pentapeptide-1 (CAS 97530-32-0) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Acetyl Pentapeptide-1 is positioned as a skin-barrier-reinforcing peptide evaluated for its ability to stimulate epidermal differentiation markers and improve stratum corneum integrity in leave-on formulations targeting sensitive, compromised or chronically dry skin. TCS NEXUS S.L. supplies Acetyl Pentapeptide-1 as a B2B synthetic pentapeptide for formulators developing barrier-repair and anti-ageing products.
What is the CAS number for Acetyl Pentapeptide-1?
The CAS number for Acetyl Pentapeptide-1 is 97530-32-0. The INCI name for cosmetic regulatory documentation and CPNP notification is Acetyl Pentapeptide-1; confirm CAS 97530-32-0 and INCI identity against the batch COA when building product files.
How does Acetyl Pentapeptide-1 support firmness — what is its matrix mechanism?
Acetyl Pentapeptide-1 is an N-acetylated pentapeptide positioned as a matrix-synthesis-supporting, skin-firming active. It is discussed as signalling fibroblasts to support extracellular-matrix components for the appearance of firmer, more resilient skin; the N-terminal acetylation is a stabilising modification that helps the peptide resist enzymatic breakdown in the formula and on skin.
What use level of Acetyl Pentapeptide-1 is typical, and how should it be evaluated?
Treat the use level as project-specific and establish it conservatively for your base and claim rather than to a fixed figure; it is often a trade solution, so confirm your dosing basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Acetyl Pentapeptide-1 in a firmness system?
Acetyl Pentapeptide-1 layers with collagen-matrix peptides such as Matrixyl and Palmitoyl Tripeptide-1, with GHK-Cu and with niacinamide for firmness and density positioning. It is water-soluble; confirm combined stability and pH in the finished base.
What does the N-acetylation add to Acetyl Pentapeptide-1?
The N-terminal acetyl cap is a stabilising modification: it protects the peptide from aminopeptidase breakdown, helping it stay intact and active longer in the formula and on skin, while the sequence carries a matrix-synthesis firming signal. Acetyl Pentapeptide-1 is freely water-soluble and dissolves directly in the aqueous phase.
What addition temperature is recommended for Acetyl Pentapeptide-1 during manufacturing?
Introduce Acetyl Pentapeptide-1 during the cool-down phase at temperatures below 45°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Acetyl Pentapeptide-1 stable in a finished formula?
Acetyl Pentapeptide-1 is most stable at roughly pH 4.5–7.0; confirm the finished-product pH after all actives are incorporated and evaluate combined stability with low-pH actives such as ascorbic acid.
Is Acetyl Pentapeptide-1 compatible with other actives in multi-active cosmetic systems?
Acetyl Pentapeptide-1 is compatible with standard cosmetic actives at pH 5.0–7.5 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Acetyl Pentapeptide-1 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Acetyl Pentapeptide-1 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 97530-32-0 and INCI name Acetyl Pentapeptide-1 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Acetyl Pentapeptide-1 be stored?
Store Acetyl Pentapeptide-1 sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Acetyl Pentapeptide-1?
TCS NEXUS S.L. provides COA (confirming CAS 97530-32-0 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Acetyl Pentapeptide-1. Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Acetyl Pentapeptide-1?
Sample and bulk quantities for Acetyl Pentapeptide-1 are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.