Tetrapeptide-3 is a four-amino-acid peptide designed to support dermal matrix density and firmness. It belongs to the category of signal peptides that interact with fibroblast receptors to upregulate structural protein synthesis. While less commercially famous than Matrixyl or Argireline, it fills a specific niche in formulations targeting skin firmness and elasticity loss in mature skin.
Mechanism and Efficacy
Tetrapeptide-3 activates fibroblast surface receptors involved in extracellular matrix maintenance. In human dermal fibroblast cultures, treatment with 50 ppm Tetrapeptide-3 for 72 hours resulted in a 28% increase in type I collagen and a 22% increase in elastin mRNA expression versus untreated controls. At 100 ppm, fibronectin production increased by 35%, suggesting broad ECM stimulation rather than single-target activity.
This multi-target profile makes Tetrapeptide-3 particularly useful in anti-aging formulations where the goal is overall dermal density improvement rather than targeting a single wrinkle mechanism.
Formulation Guide
- Use level: 50-200 ppm in final product.
- Addition: Cool-down phase below 45C. Water-soluble.
- pH: Stable 5.0-7.0.
- Compatibility: Compatible with most cosmetic ingredients. Pairs well with Acetyl Tetrapeptide-9 (lumican stimulation) for complementary matrix support.
- Storage: 2-8C, protect from light.
FAQ
What makes Tetrapeptide-3 different from Tetrapeptide-9?
Tetrapeptide-3 primarily targets collagen and elastin directly. Acetyl Tetrapeptide-9 stimulates lumican, a proteoglycan that organizes collagen fibrils. They work at different levels of matrix organization and combine well.
Samples and MOQ?
Evaluation from 1g. Production MOQ 100g. TCS NEXUS S.L., Valencia Spain. EU delivery 5-7 days.
| Parameter | Specification |
|---|---|
| INCI | Tetrapeptide-3 |
| CAS | 827306-97-8 |
| MW | ~490 g/mol |
| Purity | Over 98% HPLC |
Technical Fit and Sourcing Focus
Tetrapeptide-3 supports the portfolio around scalp-care, lash, and hair-focused peptide sourcing where structural support claims matter more than generic anti-aging copy.
Best-Fit Applications
- Hair-care and scalp-support cosmetic projects
- Brow, lash, and follicle-adjacent peptide concepts
- Programs needing peptide pages outside standard facial anti-aging themes
How This Page Fits the Core Peptide Cluster: This page is intentionally linked with adjacent anti-aging, brightening, repair, and matrix-support peptides so crawlers can follow a tighter topical path across the site.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
Why keep Tetrapeptide-3 in the priority set if the page is shorter than others?
Its topic is still aligned with the current peptide positioning and it helps build a relevant hair and scalp-care branch within the site, which is more useful than preserving off-topic historical URLs.
Can Tetrapeptide-3 inquiries be grouped with other hair-related peptides?
Yes. TCS can coordinate technical review and sourcing discussions across adjacent peptides used in scalp, lash, and conditioning-oriented development.
Do you provide COA documents for Tetrapeptide-3 Supplier Europe?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for Tetrapeptide-3 Supplier Europe?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for Tetrapeptide-3 Supplier Europe?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.