Acetyl Decapeptide-3 (Rejuline) (CAS 935288-50-9) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. A freely water-soluble peptide, it dissolves directly in aqueous concentrates without co-solvents at pH 4.5–7.5, with cool-down addition below 45°C recommended in standard serum and leave-on manufacturing protocols.
> Technical Specifications
| Product Name | Acetyl Decapeptide-3 (Rejuline) |
|---|---|
| Molecular Structure |  |
| CAS Number | 935288-50-9 |
| Alias / Common Name | Acetyl Decapeptide-3; Rejuline; Ac-Tyr-Arg-Ser-Arg-Lys-Tyr-Thr-Ser-Trp-Tyr-NH2 |
| Molecular Formula | C68H95N19O17 |
| Molecular Weight | 1450.6 g/mol |
| INCI Name | Acetyl Decapeptide-3 |
| Peptide Sequence | Ac-Tyr-Arg-Ser-Arg-Lys-Tyr-Thr-Ser-Trp-Tyr-NH2 — Rejuline multi-target anti-wrinkle decapeptide (SNARE/MMP/epidermal) |
| Functional Class | Synthetic decapeptide; multi-target anti-wrinkle active; SNARE/MMP/epidermal renewal modulator |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Freely water-soluble; dissolve in deionised water or aqueous phase at ambient temperature; no co-solvent required |
| pH Stability | Optimal stability at pH 4.5–7.5; confirm in the complete formulation after all actives |
| Storage | Store sealed below 25°C in cool, dry, light-protected conditions; follow batch COA and SDS |
> Mechanism & Positioning
Acetyl Decapeptide-3 (Rejuline, Ac-YRSRKYTSWRY-NH2, CAS 935288-50-9) is a 10-residue synthetic tyrosine- and arginine-rich amide decapeptide designed as a multi-target anti-wrinkle active addressing three distinct wrinkle-formation mechanisms simultaneously. Published Acetyl Decapeptide-3 literature discusses SNARE complex modulation — the decapeptide sequence contains SNAP-25 domain-homologous elements relevant to presynaptic neurotransmitter vesicle release attenuation — alongside MMP-1 (interstitial collagenase) and MMP-2 (gelatinase A) activity modulation to prevent ECM collagen degradation. Cell-based neuromuscular and fibroblast studies document presynaptic acetylcholine release reduction and MMP-related matrix degradation pathway attenuation in model assay systems. Multi-mechanism anti-wrinkle model data also notes epidermal renewal-related activity in keratinocyte assay systems — the Trp-Tyr C-terminal sequence has been discussed in the context of EGF receptor-adjacent pathway signalling that supports keratinocyte proliferation and epidermal turnover, providing three-mechanism coverage across expression wrinkles (SNARE), ECM degradation (MMP) and epidermal renewal (keratinocyte pathway) in a single active.
Based on available in vitro data, Acetyl Decapeptide-3 (Rejuline) is positioned for comprehensive multi-target anti-wrinkle serum, advanced age-care concentrate and premium anti-aging formulation concepts. For complementary neuromuscular positioning, Rejuline (SNARE component) may be evaluated alongside Argireline (Acetyl Hexapeptide-8) (primary SNARE complex inhibitor) and Matrixyl (matrix synthesis) for a combined three-mechanism anti-wrinkle architecture.
> Application Concepts
Multi-Target Anti-Wrinkle Serum Architecture
Acetyl Decapeptide-3 (Rejuline) dissolves freely in deionised water and aqueous serum bases at 0.001–0.01% (w/w) without co-solvent. Introduce during the cool-down phase below 45°C; standard aqueous serum protocols are compatible. For the broadest anti-wrinkle positioning, combine Rejuline (SNARE/MMP/epidermal) with Argireline (SNARE primary), Matrixyl (matrix synthesis) and Leuphasyl (GABAergic Ca²⁺) in a single concentrated multi-mechanism serum. All four are water-soluble and pH-compatible at 4.5–7.5. The Trp residue in the decapeptide can be susceptible to UV-induced oxidation — protect formulations from direct UV exposure during storage and consider antioxidant co-actives. Confirm assay retention and stability at 40°C/75% RH before scale-up.
SNARE + MMP Dual-Mechanism Anti-Wrinkle Design
Acetyl Decapeptide-3’s dual SNARE/MMP mechanism addresses the two primary pathways of wrinkle formation and deepening: (i) expression wrinkle formation driven by repeated neuromuscular contraction (SNARE pathway); and (ii) structural wrinkle deepening driven by collagen ECM degradation by MMP-1 and MMP-2 (gelatinase/collagenase pathway). Most single-mechanism neuromuscular peptides (Argireline, Leuphasyl, Syn-Ake) address only the expression pathway; most matrix synthesis peptides (Matrixyl, GHK) address only the structural pathway. Rejuline combines both directions in a single active, making it an efficient choice for formulation briefs where a single “multi-mechanism” active with simplified INCI declaration is preferred over multiple individual peptides. Confirm SNARE and MMP activity in the target assay systems.
Premium Anti-Age Formulation with Epidermal Renewal Support
The epidermal renewal component of Acetyl Decapeptide-3 (Rejuline) positions it for premium anti-age serums where epidermal turnover alongside dermis remodelling are combined claim directions. At 0.001–0.01% in a concentrated anti-age serum, Rejuline contributes neuromuscular (SNARE), matrix protection (MMP) and epidermal renewal (keratinocyte pathway) activity within a single water-soluble peptide addition during cool-down. Combine with Matrixyl (new collagen synthesis via TGF-β1) and GHK-Cu (LOX crosslinking) for comprehensive anti-wrinkle architecture covering expression, degradation, synthesis and crosslinking pathways. Confirm Trp residue stability in the complete formulation.
> Handling & Formulation Notes
Dissolve Acetyl Decapeptide-3 (Rejuline) in deionised water or the aqueous phase at ambient temperature at 0.001–0.01% (w/w). Freely water-soluble at these concentrations. Introduce during cool-down below 45°C. The Trp residue is susceptible to UV and oxidative degradation — formulate in UV-protected packaging and evaluate antioxidant co-actives (EDTA, tocopherol) for stability support. Maintain pH within 4.5–7.5.
Evaluate Trp-containing peptide stability under oxidative conditions (H₂O₂, peroxide-generating preservatives). Confirm peptide assay retention by HPLC after accelerated stability at 40°C/75% RH in UV-protected packaging before production scale-up.
> Supply & Documentation
Acetyl Decapeptide-3 (Rejuline) (CAS 935288-50-9) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Acetyl Decapeptide-3 (Rejuline) is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Acetyl Decapeptide-3 (Rejuline)?
Acetyl Decapeptide-3 (Rejuline) (CAS 935288-50-9) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Acetyl Decapeptide-3 (Rejuline) is positioned as an anti-ageing decapeptide targeting collagen synthesis and dermal fibroblast function — evaluated in anti-wrinkle serums and emulsions where loss of dermal density and fibrillar collagen contributes to visible wrinkling and sagging. TCS NEXUS S.L. supplies Acetyl Decapeptide-3 as a B2B pure acetylated decapeptide for anti-ageing formulation specialists.
What is the CAS number for Acetyl Decapeptide-3 (Rejuline)?
The CAS number for Acetyl Decapeptide-3 (Rejuline) is 935288-50-9. The INCI name for cosmetic regulatory documentation and CPNP notification is Acetyl Decapeptide-3; confirm CAS 935288-50-9 and INCI identity against the batch COA when building product files.
How does Acetyl Decapeptide-3 (Rejuline) smooth wrinkles — what is its multi-target action?
Acetyl Decapeptide-3 (Rejuline) is a ten-amino-acid peptide positioned as a multi-target anti-wrinkle active. It is discussed as acting on several fronts at once — supporting epidermal renewal, moderating matrix-metalloproteinase (MMP) breakdown of the matrix, and touching the SNARE expression-line pathway — so it is framed as a broad-spectrum smoothing peptide rather than a single-mechanism active.
What use level of Rejuline is typical, and how should it be evaluated?
Establish the use level conservatively for your base and claim rather than to a fixed figure; Rejuline is usually a trade solution, so confirm whether you dose on a pure-peptide or solution basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Rejuline in a broad-spectrum anti-wrinkle system?
As a multi-target peptide, Rejuline layers with collagen-matrix peptides such as Matrixyl and GHK-Cu, with expression-line peptides such as Argireline, and with niacinamide and antioxidants for a broad age-care system. It is water-soluble; confirm combined stability and pH in the finished base.
What makes Acetyl Decapeptide-3 distinct — its multi-target design?
Its distinctive feature is breadth: rather than one target, Acetyl Decapeptide-3 is positioned to touch epidermal renewal, MMP-mediated matrix breakdown and the SNARE expression-line route together, aiming for all-round smoothing in a single ingredient. That makes it a versatile base peptide that other, more targeted peptides can build on. It is freely water-soluble.
What addition temperature is recommended for Acetyl Decapeptide-3 (Rejuline) during manufacturing?
Introduce Acetyl Decapeptide-3 (Rejuline) during the cool-down phase at temperatures below 45°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Rejuline stable in a finished formula?
Acetyl Decapeptide-3 is most stable at roughly pH 4.5–7.0, matching serum and emulsion targets; confirm the finished-product pH after all actives are incorporated and evaluate combined stability with low-pH actives such as ascorbic acid.
Is Acetyl Decapeptide-3 (Rejuline) compatible with other actives in multi-active cosmetic systems?
Acetyl Decapeptide-3 (Rejuline) is compatible with standard cosmetic actives at pH 4.5–7.5 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Acetyl Decapeptide-3 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Acetyl Decapeptide-3 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 935288-50-9 and INCI name Acetyl Decapeptide-3 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Acetyl Decapeptide-3 (Rejuline) be stored?
Store Acetyl Decapeptide-3 (Rejuline) sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Acetyl Decapeptide-3 (Rejuline)?
TCS NEXUS S.L. provides COA (confirming CAS 935288-50-9 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Acetyl Decapeptide-3 (Rejuline). Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Acetyl Decapeptide-3 (Rejuline)?
Sample and bulk quantities for Acetyl Decapeptide-3 (Rejuline) are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.