Palmitoyl Tetrapeptide-10 (CAS 887140-79-6) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. With limited direct water solubility, it requires propylene glycol or ethanol pre-dispersion before aqueous dilution, at pH 4.5–7.0, with incorporation below 40°C in standard emulsion manufacturing protocols.
> Technical Specifications
| Product Name | Palmitoyl Tetrapeptide-10 |
|---|---|
| Molecular Structure |  |
| CAS Number | 887140-79-6 |
| Alias / Common Name | Palmitoyl Tetrapeptide-10; Pal-KTFK (palmitoyl-Lys-Thr-Phe-Lys) |
| Molecular Formula | C41H72N6O7 |
| Molecular Weight | 761.0 g/mol |
| INCI Name | Palmitoyl Tetrapeptide-10 |
| Peptide Sequence | Palmitoyl-Lys-Thr-Phe-Lys — Pal-KTFK (ECM-active tetrapeptide with C16 lipid anchor) |
| Functional Class | Synthetic lipopeptide; ECM repair peptide; fibronectin and collagen IV deposition modulator; DEJ/basement membrane zone targeting active |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Lipopeptide; limited direct water dispersibility. Pre-disperse in propylene glycol (5–15%) or ethanol (10–20%) at 40–50°C before adding to the formulation at cool-down below 40°C. |
| pH Stability | Optimal stability at pH 4.5–7.0. Confirm stability in the complete formulation base. |
| Storage | Store sealed below 25°C in a cool, dry location protected from direct light and moisture. Follow SDS and batch COA conditions. |
> Mechanism & Positioning
Palmitoyl Tetrapeptide-10 is a synthetic lipopeptide ECM active based on the Lys-Thr-Phe-Lys (KTFK) sequence bearing a C16 palmitoyl lipid anchor for membrane affinity and transdermal delivery support. Published Palmitoyl Tetrapeptide-10 literature discusses interaction with ECM receptor and integrin-signalling pathways, modulating fibronectin and collagen IV deposition in the basement membrane zone and dermal-epidermal junction (DEJ). Cell-based fibroblast studies document upregulation of collagen IV and fibronectin secretion, with observed effects on laminin and DEJ architecture in organotypic skin models. ECM remodelling model data also notes attenuation of MMP-1 and MMP-3 collagenase activity in the dermal fibroblast system, consistent with net matrix-building activity for anti-age positioning. The palmitoyl anchor improves lipid-phase affinity and is commonly used to enhance peptide delivery across the SC lipid barrier for dermal targeting.
Palmitoyl Tetrapeptide-10 builds multi-pathway ECM repair systems with Palmitoyl Tripeptide-1 (Pal-GHK) for TGF-β/fibronectin signalling and Palmitoyl Tetrapeptide-7 (Rigin) for IL-6/TNF-α inflammatory matrix degradation control. For ECM breadth in premium age-care emulsions, add Palmitoyl Hexapeptide-12 (Biopeptide-EL) for elastin EBP pathway support. Contact info@tcspeptides.com with formulation specification.
> Application Concepts
ECM-Repair Emulsion and Lipopeptide Matrix Architecture
Palmitoyl Tetrapeptide-10 at 0.001–0.1% integrates into emulsion systems — anti-age day creams, regenerative night concentrates and serum-in-emulsion formats — where the palmitoyl anchor facilitates lipid-phase interaction and SC delivery. Pre-disperse in propylene glycol (5–15 parts PG per 1 part peptide) at 40–50°C with gentle stirring before adding to the emulsion base at cool-down below 40°C. For a multi-lipopeptide ECM system, combine Palmitoyl Tetrapeptide-10 with Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 in a shared PG pre-dispersion at combined concentrations up to 0.2% total lipopeptide — confirm PG tolerance in the final emulsion system before scale-up.
DEJ Architecture — Basement Membrane Zone Targeting as an Anti-Age Strategy
The dermal-epidermal junction (DEJ) is a critical ECM target for anti-age actives. DEJ flattening (loss of rete ridge interdigitation and anchoring fibril integrity) is a hallmark of intrinsic ageing, UV extrinsic ageing and systemic glycation. Palmitoyl Tetrapeptide-10’s collagen IV and fibronectin-upregulating activity positions it specifically in the DEJ and basement membrane zone — distinct from the papillary dermis collagen I/III targets of Palmitoyl Tripeptide-1 and Acetyl Tetrapeptide-9 (Dermican) (lumican/collagen XVII DEJ modulator). A multi-target DEJ system combining collagen IV and fibronectin (Palmitoyl Tetrapeptide-10), anchoring fibril collagen VII (retinol equivalent strategies) and lumican glycoprotein (Acetyl Tetrapeptide-9) addresses the full DEJ structural network in a comprehensive anti-age emulsion.
Premium Anti-Age Day and Night Emulsion Formats
Palmitoyl Tetrapeptide-10 at 0.001–0.1% is appropriate for premium anti-age day creams (paired with UV filters and antioxidants for photoprotection alignment), regenerative night concentrates (where ECM remodelling and synthesis activity is uninhibited by UV stress) and professional treatment serums. For night concentrate positioning, combine Palmitoyl Tetrapeptide-10 with Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7 (Rigin) and Palmitoyl Hexapeptide-12 in a rich emollient emulsion base at pH 5.5–6.5 for a four-lipopeptide ECM matrix architecture addressing collagen I/III, elastin, DEJ and inflammatory matrix degradation.
> Handling & Formulation Notes
Pre-disperse Palmitoyl Tetrapeptide-10 in propylene glycol (5–15 parts PG per 1 part peptide) at 40–50°C with gentle stirring until uniform dispersion is achieved before incorporation into the formulation. Add the PG dispersion to the emulsion base at cool-down below 40°C. Avoid direct addition of undispersed powder to hot aqueous phases. Avoid prolonged heating above 45°C to protect the palmitoyl amide bond.
Confirm stability of Palmitoyl Tetrapeptide-10 in the complete emulsion at 40°C/75% RH for 12 weeks before scale-up. Monitor lipopeptide integrity by HPLC when formulating at pH outside 4.5–7.0. Follow SDS and batch COA for storage and handling; confirm shelf life for the specific batch. EDTA at ≤0.1% is compatible as a chelating buffer in emulsion systems; avoid strong oxidising agents (H₂O₂ ≥1%, benzoyl peroxide) and high-pH bases above pH 8.0.
> Supply & Documentation
Palmitoyl Tetrapeptide-10 (CAS 887140-79-6) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Palmitoyl Tetrapeptide-10 is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Palmitoyl Tetrapeptide-10?
Palmitoyl Tetrapeptide-10 (CAS 887140-79-6) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Palmitoyl Tetrapeptide-10 is positioned as a collagen-stimulating lipopeptide that enhances dermal matrix remodelling — evaluated in anti-ageing serums and emulsions targeting skin firmness and elasticity through fibroblast ECM protein synthesis. TCS NEXUS S.L. supplies Palmitoyl Tetrapeptide-10 as a B2B active for anti-ageing formulation specialists.
What is the CAS number for Palmitoyl Tetrapeptide-10?
The CAS number for Palmitoyl Tetrapeptide-10 is 887140-79-6. The INCI name for cosmetic regulatory documentation and CPNP notification is Palmitoyl Tetrapeptide-10; confirm CAS 887140-79-6 and INCI identity against the batch COA when building product files.
How does Palmitoyl Tetrapeptide-10 support the DEJ — what is its ECM mechanism?
Palmitoyl Tetrapeptide-10 carries the Lys-Thr-Phe-Lys (KTFK) sequence on a palmitoyl anchor and is positioned as an extracellular-matrix repair peptide focused on the dermal-epidermal junction (DEJ) and basement-membrane zone. It is discussed as supporting deposition of fibronectin and collagen IV — key basement-membrane components — to reinforce the junction that ageing weakens. The palmitoyl chain aids penetration.
What use level of Palmitoyl Tetrapeptide-10 is typical, and how should it be evaluated?
Establish the use level conservatively for your base and claim rather than to a fixed figure; it is usually a trade solution, so confirm your dosing basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Palmitoyl Tetrapeptide-10 in a firmness system?
Because it reinforces the DEJ/basement membrane, Palmitoyl Tetrapeptide-10 complements dermal-collagen peptides such as Matrixyl and Palmitoyl Tripeptide-1 and the syndecan-focused Acetyl Tetrapeptide-11 (Syniorage). As a lipopeptide it needs pre-dispersion; confirm clarity and pH in the finished base.
What makes Palmitoyl Tetrapeptide-10 distinct — the basement-membrane focus?
Its distinctive focus is the dermal-epidermal junction and basement-membrane zone — supporting fibronectin and collagen IV deposition there — rather than bulk dermal collagen. That targets the junction where the epidermis anchors to the dermis, complementing peptides that work in the dermis proper. As a lipopeptide it has limited water solubility and is pre-dispersed before use.
What addition temperature is recommended for Palmitoyl Tetrapeptide-10 during manufacturing?
Introduce Palmitoyl Tetrapeptide-10 during the cool-down phase at temperatures below 40°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Palmitoyl Tetrapeptide-10 stable in an emulsion?
Palmitoyl Tetrapeptide-10 is most stable at roughly pH 4.5–7.0 in emulsion systems; confirm the finished-product pH after all actives are incorporated and evaluate combined stability with low-pH actives.
Is Palmitoyl Tetrapeptide-10 compatible with other actives in multi-active cosmetic systems?
Palmitoyl Tetrapeptide-10 is compatible with standard cosmetic actives at pH 4.5–7.0 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Palmitoyl Tetrapeptide-10 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Palmitoyl Tetrapeptide-10 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 887140-79-6 and INCI name Palmitoyl Tetrapeptide-10 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Palmitoyl Tetrapeptide-10 be stored?
Store Palmitoyl Tetrapeptide-10 sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Palmitoyl Tetrapeptide-10?
TCS NEXUS S.L. provides COA (confirming CAS 887140-79-6 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Palmitoyl Tetrapeptide-10. Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Palmitoyl Tetrapeptide-10?
Sample and bulk quantities for Palmitoyl Tetrapeptide-10 are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.