Myristoyl Pentapeptide-17 (CAS 959610-30-1) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. With limited direct water solubility, it requires propylene glycol or ethanol pre-dispersion before aqueous dilution, at pH 4.5–7.0, with incorporation below 40°C in standard emulsion manufacturing protocols.
> Technical Specifications
| Product Name | Myristoyl Pentapeptide-17 |
|---|---|
| Molecular Structure |  |
| CAS Number | 959610-30-1 |
| Alias / Common Name | Myristoyl Pentapeptide-17; Myr-YRSRK (lash keratin gene expression lipopeptide) |
| Molecular Formula | C41H81N9O6 |
| Molecular Weight | 796.1 g/mol |
| INCI Name | Myristoyl Pentapeptide-17 |
| Peptide Sequence | Myristoyl-Tyr-Arg-Ser-Arg-Lys — Myr-YRSRK (keratin synthesis stimulating lash lipopeptide) |
| Functional Class | Synthetic lipopeptide; keratin gene expression modulator; lash elongation and density active; hair shaft keratin synthesis lipopeptide |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Lipopeptide; limited direct water dispersibility. Pre-disperse in propylene glycol (5–15%) at 40–50°C before adding to the formulation at cool-down below 40°C. |
| pH Stability | Optimal stability at pH 4.5–7.0. Confirm stability in the complete formulation base. |
| Storage | Store sealed below 25°C in a cool, dry location protected from direct light and moisture. Follow SDS and batch COA conditions. |
> Mechanism & Positioning
Myristoyl Pentapeptide-17 is a synthetic C14 myristoyl lipopeptide specifically characterised for lash and hair shaft keratin gene expression modulation. Published Myristoyl Pentapeptide-17 literature discusses upregulation of keratin gene expression mediated by RNA polymerase II enzyme complex upregulation at keratin promoter regions (KRT6, KRT14, KRT17 — the intermediate filament keratins critical for hair shaft structural integrity and tensile strength) in follicular keratinocytes. Cell-based hair follicle keratinocyte studies document increased keratin protein synthesis and improved hair shaft cortex organisation in model follicle culture systems. Lash hair shaft elongation model data also notes extended growth phase signalling and increased follicle proliferative index in organotypic follicle culture assays. The C14 myristoyl anchor delivers the YRSRK peptide sequence to the lipid-rich follicle outer root sheath and hair canal environment, improving local peptide availability at the keratin synthesis site in the follicle matrix.
Myristoyl Pentapeptide-17 pairs with Biotinoyl Tripeptide-1 (Biotin-GHK) for complementary keratin synthesis/follicle anchoring coverage, and with Myristoyl Hexapeptide-16 for stem cell niche lipopeptide activation alongside keratin gene expression. For premium lash serums, combine Myristoyl Pentapeptide-17 (keratin gene expression) with Acetyl Tetrapeptide-3 (Folixyl) (5α-R / follicle anchoring) in a shared PG/aqueous vehicle for a two-active lash concentrate targeting shaft elongation and follicle retention. Contact info@tcspeptides.com with formulation specification.
> Application Concepts
Lash Elongation Serum and Keratin Lipopeptide Architecture
Myristoyl Pentapeptide-17 at 0.005–0.05% requires PG pre-dispersion (5–15 parts PG per 1 part peptide, 40–50°C) before addition to the serum base at cool-down below 40°C. It is appropriate for precision-application lash serums (mascara wand or felt-tip applicator), brow serums and lash conditioner formulations in the aqueous/PG vehicle category. For a dual-mechanism lash serum targeting both keratin shaft synthesis and follicle anchoring, combine Myristoyl Pentapeptide-17 with Biotinoyl Tripeptide-1 — the PG dispersion (Myr-PP17) and the aqueous solution (Biotin-GHK) added sequentially at cool-down into a common light serum base. Final formulation PG level from Myr-PP17 dispersion at 0.05% is typically ≤0.75% PG — well within tolerance for periorbital serum application.
Keratin Gene Expression vs Follicle Anchoring — Two Independent Lash Density Mechanisms
Lash density and length are determined by two independent follicle processes: the keratin synthesis rate in the hair matrix cortex (shaft elongation speed and diameter — targeted by Myristoyl Pentapeptide-17) and follicle anchoring and retention to the dermal sheath (determining shedding resistance — targeted by Biotinoyl Tripeptide-1 (Biotin-GHK)). Keratin gene upregulation increases shaft elongation speed and cortex structural density; follicle ECM anchoring reduces premature shedding during the catagen-to-telogen transition. Neither mechanism compensates for the other — both must be supported for comprehensive lash density improvement. A formulation combining Myristoyl Pentapeptide-17 and Biotinoyl Tripeptide-1 addresses both the shaft elongation and follicle retention axes within a single lash serum product.
Premium Lash, Brow and Periorbital Hair Density Format Applications
Myristoyl Pentapeptide-17 at 0.005–0.05% is appropriate for three high-value hair cosmetic market segments: premium lash density serums (keratin synthesis for lash shaft elongation and volume), clinical brow density concentrates (keratin upregulation for thinning brow hair shafts), and professional hair-care treatments for scalp hair shaft thickness optimisation. For lash and brow market positioning, all lipopeptide concentrations at ≤0.05% keep PG contribution ≤0.75% — appropriate for periorbital leave-on application. Evaluate eye irritation safety in the complete periorbital formulation base before market launch. Confirm stability and keratin assay retention at 40°C/75% RH for 12 weeks in the selected lash serum base.
> Handling & Formulation Notes
Pre-disperse Myristoyl Pentapeptide-17 in propylene glycol (5–15 parts PG per 1 part peptide) at 40–50°C with gentle stirring until uniform dispersion is achieved. Add the PG dispersion to the serum base at cool-down below 40°C. Avoid direct addition of undispersed powder to hot aqueous phases. Avoid prolonged heating above 45°C to protect the myristoyl amide bond.
Confirm stability of Myristoyl Pentapeptide-17 in the complete lash formulation at 40°C/75% RH for 12 weeks before scale-up. Monitor lipopeptide integrity by HPLC when formulating at pH outside 4.5–7.0. Follow SDS and batch COA for storage and handling; confirm shelf life for the specific batch. EDTA at ≤0.1% is compatible as a chelating buffer in emulsion systems; avoid strong oxidising agents (H₂O₂ ≥1%, benzoyl peroxide) and high-pH bases above pH 8.0.
> Supply & Documentation
Myristoyl Pentapeptide-17 (CAS 959610-30-1) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Myristoyl Pentapeptide-17 is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Myristoyl Pentapeptide-17?
Myristoyl Pentapeptide-17 (CAS 959610-30-1) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Myristoyl Pentapeptide-17 is positioned as a lipopeptide stimulating eyelash keratin gene expression — evaluated as the primary active in eyelash serum formulations targeting increased lash length, density and thickness. TCS NEXUS S.L. supplies Myristoyl Pentapeptide-17 as a B2B active for formulators developing eyelash enhancement leave-on products.
What is the CAS number for Myristoyl Pentapeptide-17?
The CAS number for Myristoyl Pentapeptide-17 is 959610-30-1. The INCI name for cosmetic regulatory documentation and CPNP notification is Myristoyl Pentapeptide-17; confirm CAS 959610-30-1 and INCI identity against the batch COA when building product files.
How does Myristoyl Pentapeptide-17 support lash growth — what is the keratin mechanism?
Myristoyl Pentapeptide-17 (Myr-YRSRK) is a lipopeptide reported to stimulate expression of keratin genes in the hair follicle, supporting the keratin building blocks of the lash and hair shaft. By promoting keratin production it is positioned for the appearance of longer, denser lashes and brows in cosmetic lash-conditioning products. The myristoyl chain provides lipophilicity for delivery.
What use level of Myristoyl Pentapeptide-17 is typical, and how should it be evaluated?
There is no one-size-fits-all dose: establish the use level conservatively for your base and claim; it is commonly a diluted trade solution, so confirm your dosing basis. We provide the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Myristoyl Pentapeptide-17 in a lash serum?
Myristoyl Pentapeptide-17 (keratin) is classically paired with Myristoyl Hexapeptide-16 (stem-cell-niche activation) in lash-conditioning serums, and combines with Biotinoyl Tripeptide-1, panthenol and caffeine. As a lipopeptide it needs pre-dispersion; confirm clarity and pH in the finished serum base.
What makes Myristoyl Pentapeptide-17 distinct — the keratin-gene focus?
Its distinctive action is on keratin gene expression — building the structural keratin of the lash and hair shaft — which is different from follicle anchoring (Biotinoyl Tripeptide-1) or stem-cell activation (Myristoyl Hexapeptide-16). That is why lash serums often combine it with those complementary peptides. As a lipopeptide it has limited water solubility and is pre-dispersed before use.
What addition temperature is recommended for Myristoyl Pentapeptide-17 during manufacturing?
Introduce Myristoyl Pentapeptide-17 during the cool-down phase at temperatures below 40°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Myristoyl Pentapeptide-17 stable in a finished formula?
Myristoyl Pentapeptide-17 is most stable at roughly pH 4.5–7.0; confirm the finished-product pH after all actives are incorporated and evaluate combined stability in the complete lash-serum base.
Is Myristoyl Pentapeptide-17 compatible with other actives in multi-active cosmetic systems?
Myristoyl Pentapeptide-17 is compatible with standard cosmetic actives at pH 4.5–7.0 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Myristoyl Pentapeptide-17 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Myristoyl Pentapeptide-17 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 959610-30-1 and INCI name Myristoyl Pentapeptide-17 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Myristoyl Pentapeptide-17 be stored?
Store Myristoyl Pentapeptide-17 sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Myristoyl Pentapeptide-17?
TCS NEXUS S.L. provides COA (confirming CAS 959610-30-1 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Myristoyl Pentapeptide-17. Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Myristoyl Pentapeptide-17?
Sample and bulk quantities for Myristoyl Pentapeptide-17 are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.