Myristoyl Hexapeptide-16 (CAS 959610-54-9) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. With limited direct water solubility, it requires propylene glycol or ethanol pre-dispersion before aqueous dilution, at pH 4.5–7.0, with incorporation below 40°C in standard emulsion manufacturing protocols.
> Technical Specifications
| Product Name | Myristoyl Hexapeptide-16 |
|---|---|
| Molecular Structure |  |
| CAS Number | 959610-54-9 |
| Alias / Common Name | Myristoyl Hexapeptide-16; Myr-KAFKRT (stem cell niche activation lipopeptide) |
| Molecular Formula | C47H91N9O8 |
| Molecular Weight | 910.3 g/mol |
| INCI Name | Myristoyl Hexapeptide-16 |
| Peptide Sequence | Myristoyl-Lys-Ala-Phe-Lys-Arg-Thr — Myr-KAFKRT (stem cell niche activation hexapeptide) |
| Functional Class | Synthetic lipopeptide; epidermal stem cell niche activation peptide; hair follicle bulge stem cell proliferation modulator; skin renewal active |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Lipopeptide; limited direct water dispersibility. Pre-disperse in propylene glycol (5–15%) at 40–50°C before adding to the formulation at cool-down below 40°C. |
| pH Stability | Optimal stability at pH 4.5–7.0. Confirm stability in the complete formulation base. |
| Storage | Store sealed below 25°C in a cool, dry location protected from direct light and moisture. Follow SDS and batch COA conditions. |
> Mechanism & Positioning
Myristoyl Hexapeptide-16 is a synthetic C14 myristoyl lipopeptide designed to activate the hair follicle bulge stem cell niche — the reservoir of multipotent epithelial stem cells responsible for initiating the anagen growth phase and for epidermal barrier renewal. Published Myristoyl Hexapeptide-16 literature discusses modulation of stem cell niche signalling pathways: Wnt/β-catenin receptor complex activation and Sonic Hedgehog (Shh) receptor (Smoothened/Frizzled) pathway upregulation in follicle bulge stem cells, both critical for anagen initiation and stem cell proliferative capacity. Cell-based follicle stem cell studies document increased proliferative index (Ki67 expression), reduced apoptosis markers and upregulated Wnt target genes (TCF3, CTNNB1) in bulge stem cell model systems following Myristoyl Hexapeptide-16 treatment. Hair follicle renewal model data also notes accelerated anagen initiation timing and increased follicle density in organ-cultured skin models. The myristoyl lipid anchor targets the C14 chain to hair follicle outer root sheath lipid membranes, positioning the KAFKRT stem cell activation sequence for local delivery to the bulge niche.
Myristoyl Hexapeptide-16 builds targeted stem cell plus keratin synthesis systems with Myristoyl Pentapeptide-17 (keratin gene expression in shaft) and Biotinoyl Tripeptide-1 (Biotin-GHK) (follicle ECM anchoring). For comprehensive three-mechanism lash and scalp density positioning, add Acetyl Tetrapeptide-3 (Folixyl) for 5α-R/DHT pathway coverage. Contact info@tcspeptides.com with formulation specification.
> Application Concepts
Stem Cell Niche Serum and Myristoyl Lipopeptide Architecture
Myristoyl Hexapeptide-16 at 0.005–0.05% requires PG pre-dispersion (5–15 parts PG per 1 part peptide, 40–50°C, gentle stirring) before addition to the serum or treatment base at cool-down below 40°C. It is appropriate for scalp density serums, professional hair density treatments and premium lash serums where stem cell niche activation is the primary claim basis. For a three-mechanism hair density serum, combine Myristoyl Hexapeptide-16 (stem cell niche) with Myristoyl Pentapeptide-17 (keratin synthesis) and Acetyl Tetrapeptide-3 (5α-R / DHT pathway) — with both lipopeptides in a shared PG pre-dispersion and the water-soluble tetrapeptide added from aqueous stock.
Stem Cell Niche Activation vs Keratin Gene Expression — Addressing Anagen Initiation and Shaft Synthesis Separately
Hair follicle density and shaft thickness are controlled at two distinct follicle compartments: the bulge stem cell niche (Wnt/Shh signalling → anagen initiation → follicle cycling), targeted by Myristoyl Hexapeptide-16, and the hair matrix proliferating keratinocytes (keratin gene transcription → shaft elongation rate → cortex density), targeted by Myristoyl Pentapeptide-17. Stem cell niche activation increases the number of follicles entering and maintaining anagen; keratin gene upregulation maximises shaft elongation speed in each actively growing follicle. Both mechanisms are required for optimal density outcomes — activating stem cells without supporting keratin synthesis limits shaft quality, while maximising keratin synthesis without anagen initiation limits the number of active follicles. The two myristoyl lipopeptides can be co-formulated in a shared PG pre-dispersion with no known interaction at cosmetic evaluation concentrations.
Scalp Hair Renewal, Clinical lash density and Professional Treatment Format Applications
Myristoyl Hexapeptide-16 at 0.005–0.05% targets three premium hair-care market segments: scalp hair renewal concentrates (Wnt/Shh anagen initiation for thinning or post-partum hair loss), clinical lash density serums (bulge stem cell activation for lash follicle density and retention cycle optimisation), and professional salon/clinic treatment products (high-potency stem cell niche actives for in-salon scalp treatment protocols). For clinical channel positioning, combine Myristoyl Hexapeptide-16 with Acetyl Tetrapeptide-3 (Folixyl), Myristoyl Pentapeptide-17 and Biotinoyl Tripeptide-1 for a four-mechanism professional hair density treatment targeting stem cell niche, keratin synthesis, 5α-R pathway and follicle ECM anchoring.
> Handling & Formulation Notes
Pre-disperse Myristoyl Hexapeptide-16 in propylene glycol (5–15 parts PG per 1 part peptide) at 40–50°C with gentle stirring until uniform dispersion is achieved before incorporation into the formulation. Add the PG dispersion to the serum or treatment base at cool-down below 40°C. Avoid direct addition of undispersed powder to hot aqueous phases. Avoid prolonged heating above 45°C to protect the myristoyl amide bond.
Confirm stability of Myristoyl Hexapeptide-16 in the complete formulation at 40°C/75% RH for 12 weeks before scale-up. Monitor lipopeptide integrity by HPLC when formulating at pH outside 4.5–7.0. Follow SDS and batch COA for storage and handling; confirm shelf life for the specific batch. EDTA at ≤0.1% is compatible as a chelating buffer in emulsion systems; avoid strong oxidising agents (H₂O₂ ≥1%, benzoyl peroxide) and high-pH bases above pH 8.0.
> Supply & Documentation
Myristoyl Hexapeptide-16 (CAS 959610-54-9) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Myristoyl Hexapeptide-16 is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Myristoyl Hexapeptide-16?
Myristoyl Hexapeptide-16 (CAS 959610-54-9) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Myristoyl Hexapeptide-16 is positioned as a lipopeptide supporting eyelash and eyebrow hair density — evaluated in lash-conditioning serums and brow growth treatments where follicle stimulation and anchoring are the key efficacy claims. TCS NEXUS S.L. supplies Myristoyl Hexapeptide-16 as a B2B active for formulators developing targeted lash and brow formulations.
What is the CAS number for Myristoyl Hexapeptide-16?
The CAS number for Myristoyl Hexapeptide-16 is 959610-54-9. The INCI name for cosmetic regulatory documentation and CPNP notification is Myristoyl Hexapeptide-16; confirm CAS 959610-54-9 and INCI identity against the batch COA when building product files.
How does Myristoyl Hexapeptide-16 support renewal — what is the stem-cell-niche mechanism?
Myristoyl Hexapeptide-16 (Myr-KAFKRT) is a lipopeptide reported to activate the epidermal and hair-follicle-bulge stem cell niche, supporting the pool of cells that drive renewal and the anagen (growth) phase appearance. In lash and hair conditioning it is positioned for the appearance of density and renewed growth. The myristoyl chain aids delivery.
What use level of Myristoyl Hexapeptide-16 is typical, and how should it be evaluated?
Because the effective level shifts with formulation and claim, build it up conservatively from your own evaluation instead of fixing on one number; it is usually a trade solution, so confirm your dosing basis. We provide the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Myristoyl Hexapeptide-16 in a lash serum?
Myristoyl Hexapeptide-16 (stem-cell niche) is the classic partner of Myristoyl Pentapeptide-17 (keratin) in lash-conditioning serums — pairing renewal with keratin building — and it combines with Biotinoyl Tripeptide-1, panthenol and hyaluronic acid. As a lipopeptide it needs pre-dispersion; confirm clarity and pH in the finished base.
What makes Myristoyl Hexapeptide-16 distinct — stem-cell-niche activation?
Its distinctive action is activating the stem-cell niche of the epidermis and follicle bulge — addressing the renewal source — rather than building keratin (Myristoyl Pentapeptide-17) or anchoring (Biotinoyl Tripeptide-1). Combining renewal with keratin synthesis is why the two myristoyl lash peptides are used together. As a lipopeptide it has limited water solubility and is pre-dispersed.
What addition temperature is recommended for Myristoyl Hexapeptide-16 during manufacturing?
Introduce Myristoyl Hexapeptide-16 during the cool-down phase at temperatures below 40°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Myristoyl Hexapeptide-16 stable in a finished formula?
Myristoyl Hexapeptide-16 is most stable at roughly pH 4.5–7.0; confirm the finished-product pH after all actives are incorporated and evaluate combined stability in the complete serum base.
Is Myristoyl Hexapeptide-16 compatible with other actives in multi-active cosmetic systems?
Myristoyl Hexapeptide-16 is compatible with standard cosmetic actives at pH 4.5–7.0 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Myristoyl Hexapeptide-16 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Myristoyl Hexapeptide-16 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 959610-54-9 and INCI name Myristoyl Hexapeptide-16 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Myristoyl Hexapeptide-16 be stored?
Store Myristoyl Hexapeptide-16 sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Myristoyl Hexapeptide-16?
TCS NEXUS S.L. provides COA (confirming CAS 959610-54-9 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Myristoyl Hexapeptide-16. Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Myristoyl Hexapeptide-16?
Sample and bulk quantities for Myristoyl Hexapeptide-16 are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.