S-Hydroxypropyl Tetrahydropyrantriol (CAS 868156-46-1) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing GAG pathway support, skin-conditioning serum and premium daily-care raw material applications. A freely water-soluble C-xyloside derivative, it dissolves directly in aqueous concentrates without co-solvents at pH 4.5–7.5, with cool-down addition below 40°C recommended in standard serum and emulsion manufacturing protocols.
> Technical Specifications
| Product Name | S-Hydroxypropyl Tetrahydropyrantriol |
|---|---|
| Molecular Structure |  |
| CAS Number | 868156-46-1 |
| Alias / Common Name | S-Hydroxypropyl Tetrahydropyrantriol; S-Pro-Xylane; Hydroxypropyl Tetrahydropyrantriol; C-xyloside skin active |
| Molecular Formula | C8H16O5 |
| Molecular Weight | 192.21 g/mol |
| INCI Name | Hydroxypropyl Tetrahydropyrantriol |
| Functional Class | Synthetic C-xyloside; sugar-derived GAG pathway modulator; skin conditioning active |
| Purity / Assay | ≥95% (HPLC or equivalent); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Freely water-soluble; dissolve in deionised water or aqueous phase at ambient temperature; no co-solvent or glycol pre-mix required |
| pH Stability | Optimal stability at pH 4.5–7.5; confirm in target base after all actives incorporated |
| Storage | Store sealed in cool, dry conditions protected from direct light and moisture; follow batch COA and SDS |
> Mechanism & Positioning
S-Hydroxypropyl Tetrahydropyrantriol (CAS 868156-46-1) is a synthetic C-xyloside structural analog of D-xylose, designed to interact with glycosaminoglycan (GAG) biosynthesis pathways in dermal fibroblasts. In the Golgi, GAG chain assembly is initiated by xylosyltransferase-mediated xylose addition to core proteins of proteoglycans such as versican, decorin and biglycan — and C-xyloside analogs such as S-Hydroxypropyl Tetrahydropyrantriol present structural features that interact with this biosynthesis framework. Published S-Hydroxypropyl Tetrahydropyrantriol literature discusses that the compound functions as a structural xylose mimic, modulating chondroitin sulfate (CS) and dermatan sulfate (DS) glycosaminoglycan chain assembly in dermal fibroblast systems. Cell-based fibroblast studies document changes in GAG biosynthesis profile, with modulation of CS/DS proteoglycan output — versican and decorin are structural and regulatory proteoglycans contributing to dermal ECM architecture, water-binding capacity and mechanical properties. Fibroblast ECM model data also notes effects on hyaluronic acid synthase (HAS-2) activity in the context of C-xyloside analogs in dermal cell assay systems, with associated observations on hyaluronic acid–proteoglycan network interactions in the ECM.
Based on available in vitro data, formulators position S-Hydroxypropyl Tetrahydropyrantriol for skin-conditioning, proteoglycan pathway support and premium daily-care serum concepts where ECM structural pathway modulation is the primary mechanistic direction. The GAG/proteoglycan pathway differentiates it from fibronectin-receptor signal peptides such as Matrixyl (Palmitoyl Pentapeptide-4/3) (TGF-β agonism) and copper-delivery actives such as GHK-Cu (Copper Tripeptide-1 HCl) (LOX pathway), enabling independent pathway combination in premium multi-active age-care architecture. For multi-pathway positioning, S-Hydroxypropyl Tetrahydropyrantriol may also be evaluated alongside Ectoin for complementary ECM stabilisation and stress-protection positioning.
> Application Concepts
Skin-Conditioning and Age-Care Serum Architecture
S-Hydroxypropyl Tetrahydropyrantriol is freely water-soluble and dissolves directly in glycerin–water concentrates, hyaluronic acid solutions and buffered aqueous serum bases at evaluation concentrations of 0.5–3.0% without co-solvent or emulsifier pre-dispersion. Introduce during the cool-down phase below 40°C to avoid unnecessary thermal exposure during manufacture; standard aqueous serum cool-down protocols are fully compatible. The water-soluble, low-molecular-weight profile makes it a clean addition to transparent serum formats, layering concentrates and pump-format daily serums where clarity and a simple INCI declaration are formulation priorities. For multi-mechanism ECM positioning, S-Hydroxypropyl Tetrahydropyrantriol (GAG/proteoglycan pathway) may be combined with hyaluronic acid (3 MDa HA for surface film, 50–300 kDa HA for deeper skin penetration) to address both proteoglycan synthesis and direct hyaluronic acid supply — independent mechanisms that do not require separate formulation phases. Confirm pH (4.5–7.5), clarity and assay retention via accelerated stability testing at 40°C/75% RH before scale-up.
Multi-Active ECM Support and Premium Age-Care Systems
S-Hydroxypropyl Tetrahydropyrantriol targets the CS/DS proteoglycan synthesis pathway — a distinct mechanistic level from fibronectin-receptor TGF-β signalling, copper-dependent LOX crosslinking or SNARE-complex neuromuscular modulation. This mechanistic independence enables non-competing combination with Matrixyl (Palmitoyl Pentapeptide-4/3) for fibronectin-receptor TGF-β matrix signalling, GHK-Cu (Copper Tripeptide-1) for LOX-mediated collagen and elastin fibre crosslinking, and Ectoin for extremolyte-based ECM stabilisation and stress protection — each pathway addressing a different aspect of dermal ECM architecture. When combining with ascorbic acid (typically pH 2.5–4.0), evaluate S-Hydroxypropyl Tetrahydropyrantriol stability below pH 4.5 or consider a pH-zoned or separate-step delivery system. Confirm combined assay retention, pH stability and preservative compatibility in the finished concentrate before committing to scale-up batches.
Daily-Care Moisturiser and Leave-On Formulation Formats
At 0.5–3.0%, S-Hydroxypropyl Tetrahydropyrantriol integrates into standard o/w emulsion bases — day creams, daily moisturisers and multi-step moisturising concentrates — without auxiliary solvents or special dispersion requirements. It is compatible with standard daily-care actives including niacinamide (2–5%), panthenol (1–3%), glycerin and ceramide dispersions in standard aqueous-phase addition protocols. The absence of co-solvent requirements simplifies INCI declaration and keeps the aqueous phase clean for sensitive-skin and minimal-formulation positioning. Evaluate preservative compatibility with phenoxyethanol–ethylhexylglycerin systems at target pH 5.5–6.5; confirm compatibility with any chelating agents (EDTA, EDDS) present in the preservative or base system. Run accelerated stability testing at 40°C/75% RH across the full shelf-life period and confirm assay and pH stability before committing to production-scale batches.
> Handling & Formulation Notes
Dissolve S-Hydroxypropyl Tetrahydropyrantriol in deionised water or the aqueous phase at ambient temperature; the ingredient is freely water-soluble and does not require co-solvent, glycol pre-mix or surfactant dispersion. Introduce the aqueous solution during the cool-down phase at temperatures below 40°C — avoid prolonged exposure to temperatures above 45°C. Maintain formulation pH within 4.5–7.5 for optimal stability; confirm pH in the finished batch after all acidic actives, buffering agents and preservation systems are incorporated.
Evaluate compatibility with chelating agents (EDTA, EDDS) at typical cosmetic concentrations (0.05–0.1%), and with strongly acidic actives such as AHAs and ascorbic acid at low pH — confirm appearance, pH drift and assay retention across the full formulation base. Avoid prolonged contact with strong oxidising agents. Confirm colour, clarity and assay stability via accelerated stability testing at 40°C/75% RH across the intended shelf-life period before scale-up to production batches.
> Supply & Documentation
S-Hydroxypropyl Tetrahydropyrantriol (CAS 868156-46-1) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
S-Hydroxypropyl Tetrahydropyrantriol is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is S-Hydroxypropyl Tetrahydropyrantriol?
S-Hydroxypropyl Tetrahydropyrantriol (CAS 868156-46-1) is a synthetic C-xyloside cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain). It is a structural analog of D-xylose designed to interact with glycosaminoglycan (GAG) biosynthesis pathways — specifically chondroitin sulfate (CS) and dermatan sulfate (DS) proteoglycan synthesis in dermal fibroblasts. It is supplied as a B2B ingredient for skin-conditioning serum, ECM support and premium age-care formulation concepts.
What is the CAS number for S-Hydroxypropyl Tetrahydropyrantriol, and what is “S-Pro-Xylane”?
The CAS number for S-Hydroxypropyl Tetrahydropyrantriol is 868156-46-1. “S-Pro-Xylane” is a widely used commercial name for the same molecular structure (CAS 868156-46-1, INCI: Hydroxypropyl Tetrahydropyrantriol). The INCI name for cosmetic regulatory documentation and CPNP notification is Hydroxypropyl Tetrahydropyrantriol; confirm CAS 868156-46-1 and INCI identity against the batch COA when building product files.
How does S-Hydroxypropyl Tetrahydropyrantriol work at a molecular level — what is the GAG mechanism?
S-Hydroxypropyl Tetrahydropyrantriol is a C-xyloside structural analog that interacts with the glycosaminoglycan (GAG) biosynthesis pathway in the Golgi of dermal fibroblasts. GAG chain assembly on proteoglycans (versican, decorin, biglycan) is initiated by xylosyltransferase-mediated xylose priming on core proteins — and structural xylose analogs interact with this initiation framework. Published S-Hydroxypropyl Tetrahydropyrantriol literature discusses modulation of chondroitin sulfate (CS) and dermatan sulfate (DS) GAG chain assembly in dermal fibroblast systems. Cell-based fibroblast studies document changes in CS/DS proteoglycan output, with observed effects on versican and decorin — ECM structural proteoglycans that contribute to dermal architecture, water-binding and mechanical properties.
What use level of Pro-Xylane is typical, and how should it be evaluated?
Establish the use level conservatively for your base and claim rather than to a fixed figure; C-xyloside actives are supplied at defined purities, so dose on the pure-material COA basis. We provide pure material with COA — contact info@tcspeptides.com to align documentation.
What actives combine well with S-Hydroxypropyl Tetrahydropyrantriol in multi-active ECM systems?
S-Hydroxypropyl Tetrahydropyrantriol (GAG/proteoglycan pathway) builds independent multi-pathway ECM systems with: Matrixyl (Palmitoyl Pentapeptide-4/3) — fibronectin-receptor TGF-β matrix signalling; GHK-Cu (Copper Tripeptide-1) — LOX-mediated collagen and elastin fibre crosslinking; Ectoin — extremolyte-based ECM stabilisation and stress protection; hyaluronic acid — direct HA supply complementing CS/DS proteoglycan pathway modulation. Each mechanism targets a different ECM pathway and can be combined without direct competition. Confirm pH alignment, assay retention and preservative compatibility across all actives in the finished concentrate before scale-up.
What makes Pro-Xylane distinct — the C-xyloside GAG pathway?
S-Hydroxypropyl Tetrahydropyrantriol (Pro-Xylane) is a synthetic C-xyloside — a sugar-derived molecule — that is described as supporting glycosaminoglycan (GAG) synthesis at the dermal-epidermal junction, boosting the water-binding and structural GAG matrix rather than acting as a peptide signal. It is freely water-soluble and dissolves directly in the aqueous phase, which suits it to serums and essences.
How should Pro-Xylane be incorporated during manufacturing?
Pro-Xylane is freely water-soluble — dissolve it directly in the water phase without a co-solvent and add it during the cool-down phase; it tolerates normal processing well. Confirm clarity and finished pH before scale-up.
What pH range keeps Pro-Xylane stable in a finished formula?
S-Hydroxypropyl Tetrahydropyrantriol is stable across a broad range around pH 4.0–7.5, matching serum, essence and emulsion targets; confirm the finished-product pH after all actives are incorporated.
Is S-Hydroxypropyl Tetrahydropyrantriol compatible with hyaluronic acid and peptide actives in serum systems?
S-Hydroxypropyl Tetrahydropyrantriol is compatible with hyaluronic acid (multi-weight HA systems), signal peptides such as Matrixyl (Palmitoyl Pentapeptide-4/3) and carrier peptides such as GHK-Cu in standard pH 5.0–7.0 aqueous serum and emulsion bases. All are water-soluble and stable within this pH range. Evaluate combined system pH drift, clarity and peptide assay retention; confirm preservative and antioxidant compatibility in the complete multi-active formulation. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Hydroxypropyl Tetrahydropyrantriol (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Hydroxypropyl Tetrahydropyrantriol is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. It is listed in the CosIng database under its INCI name Hydroxypropyl Tetrahydropyrantriol (CAS 868156-46-1). The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 868156-46-1 and INCI name Hydroxypropyl Tetrahydropyrantriol consistently in all regulatory documentation; confirm identity and purity against the batch COA.
How should S-Hydroxypropyl Tetrahydropyrantriol be stored?
Store S-Hydroxypropyl Tetrahydropyrantriol sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life and storage conditions for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for S-Hydroxypropyl Tetrahydropyrantriol?
TCS NEXUS S.L. provides COA (confirming CAS 868156-46-1 and HPLC purity ≥95%), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for S-Hydroxypropyl Tetrahydropyrantriol. Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for S-Hydroxypropyl Tetrahydropyrantriol?
Sample and bulk quantities for S-Hydroxypropyl Tetrahydropyrantriol are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability, compatibility and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project scope and specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.