Acetyl Dipeptide-1 Cetyl Ester (CAS 196604-48-5) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. With limited direct water solubility, it requires propylene glycol or ethanol pre-dispersion before aqueous dilution, at pH 4.5–7.0, with incorporation below 40°C in standard emulsion manufacturing protocols.
> Technical Specifications
| Product Name | Acetyl Dipeptide-1 Cetyl Ester |
|---|---|
| Molecular Structure |  |
| CAS Number | 196604-48-5 |
| Alias / Common Name | Acetyl Dipeptide-1 Cetyl Ester; Ac-Tyr-Arg-OC16 |
| Molecular Formula | C33H57N5O5 |
| Molecular Weight | 603.8 g/mol |
| INCI Name | Acetyl Dipeptide-1 Cetyl Ester |
| Peptide Sequence | Acetyl-Tyr-Arg-O-Cetyl (C16 ester) — Ac-Tyr-Arg dipeptide with cetyl ester lipid anchor |
| Functional Class | Synthetic lipopeptide; epidermal tight-junction (TJ) modulator; occludin/claudin barrier-pathway active; lamellar gel network former |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Lipopeptide; limited direct water dispersibility. Pre-disperse in propylene glycol (5–15%) or heat-stable emulsifier phase before adding to the emulsion system. Add to the oil phase or emulsifier blend during emulsification step. |
| pH Stability | Optimal stability at pH 4.5–7.0 in emulsion and cream systems. Evaluate stability in the complete formulation base. |
| Storage | Store sealed below 25°C in a cool, dry location protected from direct light and moisture. Follow SDS and batch COA conditions. |
> Mechanism & Positioning
Acetyl Dipeptide-1 Cetyl Ester is a synthetic lipopeptide barrier active designed to reinforce epidermal tight-junction (TJ) protein architecture. Published Acetyl Dipeptide-1 Cetyl Ester literature discusses upregulation of occludin and claudin-1 — key transmembrane TJ proteins forming the paracellular barrier strand network in the stratum granulosum. Cell-based keratinocyte differentiation studies document increased TJ strand continuity and reduced paracellular permeability in model barrier systems. Transepidermal water loss (TEWL) reduction model data also notes improved barrier function scores in reconstructed epidermal assays, consistent with TJ reinforcement at the granular layer. The cetyl ester lipid anchor facilitates integration into lamellar lipid structures of the stratum corneum, positioning this molecule for both barrier-repair emulsions and sensitive-skin serum concepts targeting compromised TJ integrity.
Acetyl Dipeptide-1 Cetyl Ester builds multi-pathway barrier systems when combined with Palmitoyl Tripeptide-8 (Neuroskin) for neuro-inflammatory modulation alongside TJ reinforcement, and with Ectoin for extremolyte-mediated membrane stabilisation. For comprehensive skin-identical lipid barrier repair, evaluate alongside ceramide NP/AP/EOP systems. Contact info@tcspeptides.com with formulation specification and target claim direction.
> Application Concepts
Barrier-Repair Emulsion and Lipopeptide TJ Architecture
Acetyl Dipeptide-1 Cetyl Ester is formulated in emulsion systems — rich creams, barrier-repair balms and protective daily moisturisers — where its lipid anchor enables integration into the lamellar gel network. Pre-disperse the peptide in propylene glycol (5–15%) at 40–50°C with gentle stirring before adding to the emulsifier blend during the emulsification step. For aqueous serum formats, add the PG dispersion to the cool-down phase below 40°C. For sensitive-skin and compromised-barrier indication concepts, evaluate at 0.001–0.05% in a ceramide-containing emulsion base at pH 5.0–6.5. Combine with niacinamide (2–5%) for barrier ceramide co-stimulation and panthenol (1–3%) for keratinocyte differentiation support.
Tight-Junction Pathway vs Lipid Lamellar Pathway — Two Complementary Barrier Mechanisms
Epidermal barrier function requires both transcellular lipid lamellae (ceramide/cholesterol/FFA organisation in SC) and paracellular tight junctions (occludin/claudin/ZO-1 network in SG). Acetyl Dipeptide-1 Cetyl Ester targets the TJ paracellular route specifically — distinct from ceramide-based lamellar repair. This means combining Acetyl Dipeptide-1 Cetyl Ester with ceramide-rich emollients or Palmitoyl Hexapeptide-12 (Biopeptide-EL) for ECM elastin support and Palmitoyl Tripeptide-8 for neuro-barrier modulation addresses three distinct barrier-dysfunction pathways in a single premium barrier-treatment formulation.
Sensitive-Skin, Post-Procedure and Urban-Shield Format Applications
TJ reinforcement is central to three growing market segments: sensitive-skin microbiome-barrier concepts, post-procedure recovery serums (post-procedure, post-peel), and urban-pollution shield formats. In post-procedure applications, TJ protein upregulation accelerates barrier re-sealing after epidermal disruption. In urban-shield concepts, TJ integrity reduces paracellular penetration of fine particulate matter and allergens. Acetyl Dipeptide-1 Cetyl Ester at 0.001–0.05% integrates cleanly into gentle leave-on serums, cream-gels and recovery balms formulated without fragrances or high-concentration actives. Evaluate compatibility with panthenol, bisabolol and zinc-based anti-irritant systems commonly used in these market segments.
> Handling & Formulation Notes
Pre-disperse Acetyl Dipeptide-1 Cetyl Ester in propylene glycol (5–15 parts PG per 1 part peptide) at 40–50°C with gentle stirring before incorporating into the emulsion system. For emulsion formats, add the PG dispersion to the emulsifier blend during the emulsification step. For aqueous serum formats, add the PG dispersion at cool-down below 40°C. Avoid direct addition of undispersed powder to hot aqueous phases — the cetyl ester lipid anchor requires PG pre-wetting for uniform distribution.
Formulate at pH 4.5–7.0; a cream or serum base at pH 5.0–6.5 is optimal for Acetyl Dipeptide-1 Cetyl Ester stability. Confirm stability of Acetyl Dipeptide-1 Cetyl Ester in the complete emulsion system at 40°C/75% RH for 12 weeks before scale-up. Monitor ester bond integrity by HPLC if formulating at pH below 4.0 or above 8.0. Follow SDS and batch COA for storage and handling; confirm shelf life for the specific batch.
> Supply & Documentation
Acetyl Dipeptide-1 Cetyl Ester (CAS 196604-48-5) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Acetyl Dipeptide-1 Cetyl Ester is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Acetyl Dipeptide-1 Cetyl Ester?
Acetyl Dipeptide-1 Cetyl Ester (CAS 196604-48-5) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Acetyl Dipeptide-1 Cetyl Ester is positioned as a neurocalming and anti-itch active modulating TRPV1 (transient receptor potential vanilloid 1) channel sensitisation in sensory neurons — evaluated in sensitive-skin serums, anti-itch emulsions and post-procedural calming products where chronic cutaneous pain and itch perception are the primary cosmetic concerns. TCS NEXUS S.L. supplies Acetyl Dipeptide-1 Cetyl Ester as a B2B active for formulators developing neurocalming leave-on products.
What is the CAS number for Acetyl Dipeptide-1 Cetyl Ester?
The CAS number for Acetyl Dipeptide-1 Cetyl Ester is 196604-48-5. The INCI name for cosmetic regulatory documentation and CPNP notification is Acetyl Dipeptide-1 Cetyl Ester; confirm CAS 196604-48-5 and INCI identity against the batch COA when building product files.
How does Acetyl Dipeptide-1 Cetyl Ester soothe skin — what is its dual action?
Acetyl Dipeptide-1 Cetyl Ester (Ac-Tyr-Arg with a C16 cetyl-ester anchor) is a soothing lipopeptide with a dual role. The Tyr-Arg dipeptide is discussed in relation to enkephalin-like signalling that gives a comforting, de-stressed sensory feel, and it also supports epidermal tight-junction proteins (occludin/claudin) for barrier quality. Its cetyl-ester lipid part additionally helps structure a lamellar gel network in the emulsion. This makes it a comfort-and-barrier active for well-being and sensitive-skin positioning.
What use level of Acetyl Dipeptide-1 Cetyl Ester is typical, and how should it be evaluated?
Treat the use level as project-specific and establish it conservatively for your base and claim rather than to a fixed figure. We supply the pure material with COA; contact info@tcspeptides.com to align documentation.
Which actives pair with Acetyl Dipeptide-1 Cetyl Ester in a comfort system?
It pairs with sensitive-skin actives that calm neuro-sensory signals through other routes — Acetyl Tetrapeptide-15 (Skinasensyl, TRPV1) and Palmitoyl Tripeptide-8 (Neuroskin, NK1R) — and with barrier lipids, niacinamide and hydrators. As a cetyl-ester lipopeptide it belongs in the oil/emulsion phase; confirm texture, clarity and pH in the finished base.
What makes Acetyl Dipeptide-1 Cetyl Ester distinct — the cetyl-ester lipopeptide design?
Unlike most water-soluble peptides, Acetyl Dipeptide-1 Cetyl Ester carries a C16 cetyl-ester lipid tail, so it is oil-dispersible and is incorporated into the oil or emulsion phase, where it can also help build a lamellar gel network. Its dual comfort-signalling and barrier-support role sets it apart from the purely neuro-calming sensitive-skin peptides. Add it to the fatty phase rather than the water phase.
What addition temperature is recommended for Acetyl Dipeptide-1 Cetyl Ester during manufacturing?
Introduce Acetyl Dipeptide-1 Cetyl Ester during the cool-down phase at temperatures below 40°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Acetyl Dipeptide-1 Cetyl Ester stable in an emulsion?
Acetyl Dipeptide-1 Cetyl Ester is most stable at roughly pH 4.5–7.0 in emulsion systems; confirm the finished-product pH after all actives are incorporated and verify emulsion texture and stability given its lamellar-network contribution.
Is Acetyl Dipeptide-1 Cetyl Ester compatible with other actives in multi-active cosmetic systems?
Acetyl Dipeptide-1 Cetyl Ester is compatible with standard cosmetic actives at pH 4.5–7.0 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Acetyl Dipeptide-1 Cetyl Ester (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Acetyl Dipeptide-1 Cetyl Ester is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 196604-48-5 and INCI name Acetyl Dipeptide-1 Cetyl Ester consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Acetyl Dipeptide-1 Cetyl Ester be stored?
Store Acetyl Dipeptide-1 Cetyl Ester sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Acetyl Dipeptide-1 Cetyl Ester?
TCS NEXUS S.L. provides COA (confirming CAS 196604-48-5 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Acetyl Dipeptide-1 Cetyl Ester. Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Acetyl Dipeptide-1 Cetyl Ester?
Sample and bulk quantities for Acetyl Dipeptide-1 Cetyl Ester are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.