Acetyl Tetrapeptide-15 (Skinasensyl) (CAS 928007-64-1) is supplied by TCS NEXUS S.L. (Valencia, Spain) for European cosmetic formulators, brand R&D teams and B2B buyers reviewing cosmetic peptide raw material applications. A freely water-soluble peptide, it dissolves directly in aqueous concentrates without co-solvents at pH 4.5–7.0, with cool-down addition below 40°C recommended in standard serum and leave-on manufacturing protocols.
> Technical Specifications
| Product Name | Acetyl Tetrapeptide-15 (Skinasensyl) |
|---|---|
| Molecular Structure |  |
| CAS Number | 928007-64-1 |
| Alias / Common Name | Acetyl Tetrapeptide-15; Skinasensyl; Ac-YPFF-NH2 |
| Molecular Formula | C34H39N5O6 |
| Molecular Weight | 613.7 g/mol |
| INCI Name | Acetyl Tetrapeptide-15 |
| Peptide Sequence | Acetyl-Tyr-Pro-Phe-Phe-NH2 — Ac-YPFF-NH2 (TRPV1 antagonist biomimetic) |
| Functional Class | Synthetic tetrapeptide; TRPV1 (transient receptor potential vanilloid-1) modulator; substance P / neuro-inflammation pathway modulator; sensitive-skin barrier active |
| Purity / Assay | ≥98% (HPLC); confirm by batch COA |
| Appearance | White to off-white powder |
| Solubility / Handling | Freely water-soluble at evaluation concentrations (0.001–0.01%); dissolves directly in deionised water or the aqueous phase without co-solvent. Add during the cool-down phase below 40°C. |
| pH Stability | Optimal stability at pH 4.5–7.0. Confirm stability in the complete formulation base. |
| Storage | Store sealed below 25°C in a cool, dry location protected from direct light and moisture. Follow SDS and batch COA conditions. |
> Mechanism & Positioning
Acetyl Tetrapeptide-15 (Skinasensyl) is a synthetic tetrapeptide designed to modulate sensory neuro-inflammatory signalling in the skin. Published Acetyl Tetrapeptide-15 literature discusses antagonism at the TRPV1 (transient receptor potential vanilloid-1) channel — a polymodal nociceptor and heat sensor expressed on sensory nerve endings, keratinocytes and dendritic cells in the epidermis. Cell-based sensory neuron studies document reduced substance P release and attenuated CGRP (calcitonin gene-related peptide) secretion following Acetyl Tetrapeptide-15 treatment, consistent with TRPV1 pathway modulation. Reactive skin model data also notes reduction in plasma membrane depolarisation and cytokine cascade attenuation (IL-1α, TNF-α) downstream of TRPV1 activation. This mechanism positions Acetyl Tetrapeptide-15 as a primary active for reactive, sensitised and rosacea-prone skin formulations targeting the neurogenic inflammation axis.
Acetyl Tetrapeptide-15 builds multi-target sensitive-skin systems with Palmitoyl Tripeptide-8 (Neuroskin) — which targets NK1R/substance P at the receptor level — providing dual-node TRPV1-upstream and substance P-downstream signal attenuation in the same formulation. Add Ectoin for membrane-stabilising extremolyte barrier protection and Acetyl Dipeptide-1 Cetyl Ester for TJ reinforcement to address the full neuro-barrier-inflammation triad in premium sensitive-skin serums.
> Application Concepts
Sensitive-Skin Serum and TRPV1-Modulator Architecture
Acetyl Tetrapeptide-15 at 0.001–0.01% is a natural fit for water-based sensitive-skin serums, calming essences and post-shave or post-procedure recovery concentrates. Its water solubility eliminates the pre-dispersion step required for lipopeptides, making it a straightforward cool-down addition at below 40°C. At pH 5.0–6.0, it is fully compatible with standard aqueous serum bases containing carbomer or xanthan gum rheology modifiers. For reactive and rosacea-prone skin positioning, pair with bisabolol (0.1–0.5%), allantoin (0.1–0.5%) and panthenol (1–3%) as co-calming agents alongside the TRPV1-modulating peptide backbone.
TRPV1 Pathway vs NK1R Pathway — Complementary Neuro-Inflammatory Attenuation
Skin sensitisation involves two converging signalling axes: TRPV1 upstream (heat, capsaicin, acid stimulus → depolarisation → neuropeptide release) and NK1R downstream (substance P → mast cell degranulation → cytokine cascade). Acetyl Tetrapeptide-15 targets the TRPV1 upstream node; Palmitoyl Tripeptide-8 targets the NK1R downstream node. Combining both in a single sensitive-skin serum creates a two-node attenuation strategy addressing both the trigger and the effector arm of neurogenic inflammation — without redundancy, as the two peptides target non-overlapping molecular receptors in the sensory signalling cascade. Evaluate the dual-peptide combination at established individual concentrations before optimising the ratio.
Rosacea-Prone, Post-Procedure and Urban-Reactive Skin Formats
TRPV1-modulating actives are clinically relevant for three sensitised-skin market segments: rosacea-prone skin (erythema and flushing driven by TRPV1 overactivation), post-procedure recovery (sensory nerve re-sensitisation after laser or chemical peel), and urban-reactive skin (particulate-matter and pollution-triggered sensory activation). Acetyl Tetrapeptide-15 at 0.001–0.01% integrates into gentle, fragrance-free, low-irritancy bases appropriate for all three segments. For rosacea-prone positioning, evaluate alongside azelaic acid or tranexamic acid for additional vasomotor tone support. For urban-reactive formats, combine with antioxidant actives such as Ergothioneine to address oxidative-stress-triggered TRPV1 upregulation alongside direct TRPV1 antagonism.
> Handling & Formulation Notes
Dissolve Acetyl Tetrapeptide-15 directly in deionised water or the aqueous phase at evaluation concentrations (0.001–0.01%) without co-solvent or heat. Add the aqueous solution to the formulation during cool-down below 40°C. No PG pre-dispersion or special dissolution step is required at these concentrations. For concentrations above 0.05%, prepare a 1% stock solution in deionised water and add the appropriate aliquot to the batch at cool-down.
Confirm stability of Acetyl Tetrapeptide-15 (Skinasensyl) in the complete formulation at 40°C/75% RH for 12 weeks before scale-up. Monitor peptide integrity by HPLC when formulating with strong oxidising agents or at pH outside 4.5–7.0. Follow SDS and batch COA for storage and handling.
> Supply & Documentation
Acetyl Tetrapeptide-15 (Skinasensyl) (CAS 928007-64-1) is available from TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic raw material projects. Standard documentation: COA, TDS, SDS. Sample and bulk quantities are discussed on a per-project basis; contact info@tcspeptides.com to initiate a sourcing review.
TCS NEXUS S.L. supports procurement and formulation teams in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Belgium, Poland, Sweden and Portugal, as well as international buyers in the United States, Canada, Japan, South Korea, Australia and New Zealand.
> Packaging & Storage
Acetyl Tetrapeptide-15 (Skinasensyl) is supplied in sealed aluminium foil bags or bulk containers. Minimum quantities and packaging configurations are confirmed per order. Store below 25°C in a cool, dry location, away from moisture and direct light. Follow batch COA and SDS for specific storage and handling conditions.
> FAQ
What is Acetyl Tetrapeptide-15 (Skinasensyl)?
Acetyl Tetrapeptide-15 (Skinasensyl) (CAS 928007-64-1) is a cosmetic raw material supplied by TCS NEXUS S.L. (Valencia, Spain) for B2B cosmetic formulators. In cosmetic literature, Acetyl Tetrapeptide-15 (Skinasensyl) is positioned as a neurocalming peptide that reduces sensory neuropeptide release from cutaneous C-fibres — evaluated in sensitive and reactive-skin serums targeting the neurogenic inflammation cascade (redness, stinging, itch, tightness) associated with Substance P and CGRP overproduction. TCS NEXUS S.L. supplies Acetyl Tetrapeptide-15 as a B2B active for formulators developing calming and dermocosmetic leave-on products.
What is the CAS number for Acetyl Tetrapeptide-15 (Skinasensyl)?
The CAS number for Acetyl Tetrapeptide-15 (Skinasensyl) is 928007-64-1. The INCI name for cosmetic regulatory documentation and CPNP notification is Acetyl Tetrapeptide-15; confirm CAS 928007-64-1 and INCI identity against the batch COA when building product files.
How does Skinasensyl reduce skin sensitivity — what is the TRPV1 mechanism?
Acetyl Tetrapeptide-15 (Skinasensyl) is the tetrapeptide Ac-Tyr-Pro-Phe-Phe-NH2, discussed as a modulator of TRPV1, the transient receptor potential vanilloid-1 channel that senses heat, acidity and irritants and triggers the neuro-sensory signals behind stinging and discomfort. By raising the sensory threshold it is positioned to make reactive skin feel calmer and more comfortable — a sensitive-skin, tolerance-support cosmetic active.
What use level of Skinasensyl is typical, and how should it be evaluated?
There is no one-size-fits-all dose: establish the use level conservatively for your base and claim; it is often a trade solution, so confirm your dosing basis. We supply the pure material with COA — contact info@tcspeptides.com to align documentation.
Which actives pair with Skinasensyl in a sensitive-skin system?
Skinasensyl (TRPV1 pathway) is complementary to Palmitoyl Tripeptide-8 (Neuroskin), which acts on the NK1R/substance-P pathway — together addressing two neuro-sensory routes — and it combines with soothing actives, barrier lipids and ectoine-type protectants. It is water-soluble; confirm combined stability and pH in the finished base.
How does Skinasensyl differ from Neuroskin — two sensitive-skin pathways?
Both target the neuro-sensory basis of sensitive skin but through different receptors: Acetyl Tetrapeptide-15 (Skinasensyl) modulates the TRPV1 irritant-sensing channel, while Palmitoyl Tripeptide-8 (Neuroskin) modulates the NK1R substance-P receptor. Addressing both channels is why the two are often combined in tolerance-support formulas. Skinasensyl is freely water-soluble.
What addition temperature is recommended for Acetyl Tetrapeptide-15 (Skinasensyl) during manufacturing?
Introduce Acetyl Tetrapeptide-15 (Skinasensyl) during the cool-down phase at temperatures below 40°C; avoid prolonged exposure above this threshold. Standard aqueous or emulsion cool-down protocols are fully compatible with this addition requirement. Confirm thermal stability in the specific manufacturing process with accelerated stability data before committing to production scale.
What pH range keeps Skinasensyl stable in a finished formula?
Acetyl Tetrapeptide-15 is most stable at roughly pH 4.5–7.0, suited to gentle sensitive-skin products; confirm the finished-product pH after all actives are incorporated.
Is Acetyl Tetrapeptide-15 (Skinasensyl) compatible with other actives in multi-active cosmetic systems?
Acetyl Tetrapeptide-15 (Skinasensyl) is compatible with standard cosmetic actives at pH 4.5–7.0 in aqueous or emulsion systems. Evaluate combined system pH drift, clarity and assay retention; confirm preservative compatibility. Run accelerated stability testing at 40°C/75% RH before scale-up.
Is Acetyl Tetrapeptide-15 (INCI) compliant with EU Cosmetics Regulation 1223/2009?
Acetyl Tetrapeptide-15 is not listed as a restricted, prohibited or regulated substance under EU Cosmetics Regulation 1223/2009 Annexes II–VI. The finished product manufacturer is responsible for the CPSR and CPNP notification. Use CAS 928007-64-1 and INCI name Acetyl Tetrapeptide-15 consistently in all regulatory documentation; confirm purity and identity against the batch COA.
How should Acetyl Tetrapeptide-15 (Skinasensyl) be stored?
Store Acetyl Tetrapeptide-15 (Skinasensyl) sealed below 25°C in a cool, dry location protected from direct light and moisture. Once opened, reseal the container immediately. Follow specific storage and handling conditions stated in the SDS and batch COA. Confirm shelf life for the specific batch before incorporating into production formulations.
What documentation does TCS NEXUS S.L. provide for Acetyl Tetrapeptide-15 (Skinasensyl)?
TCS NEXUS S.L. provides COA (confirming CAS 928007-64-1 and HPLC purity ≥98% (HPLC)), TDS (Technical Data Sheet) and SDS (Safety Data Sheet) for Acetyl Tetrapeptide-15 (Skinasensyl). Additional documentation such as specification sheets and INCI confirmation letters is available on a per-project basis. Contact info@tcspeptides.com to initiate a documentation and sourcing discussion.
What MOQ and sample options are available for Acetyl Tetrapeptide-15 (Skinasensyl)?
Sample and bulk quantities for Acetyl Tetrapeptide-15 (Skinasensyl) are confirmed on a per-project basis through TCS NEXUS S.L. Minimum order quantities depend on current stock, packaging configuration and project scope. R&D teams are encouraged to request samples for stability and concentration-range evaluation before bulk planning. Contact info@tcspeptides.com with project specification to begin a sourcing review.
> Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.