Acetyl Octapeptide-3/1 (SNAP-8) – CAS 868844-74-0
Acetyl Octapeptide-3/1, widely referenced as SNAP-8, is an eight-amino-acid neuropeptide designed to modulate SNARE complex formation at the neuromuscular junction. With a molecular weight of approximately 1075 Da and sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, this peptide extends the established Argireline (Acetyl Hexapeptide-3) sequence by two additional amino acids, delivering measurably stronger inhibition of vesicular docking proteins.
Mechanism of Action
Dynamic expression lines form when the SNARE protein complex triggers acetylcholine release at motor nerve terminals. SNAP-8 competes with native SNAP-25 for binding positions within this ternary complex, reducing the frequency and intensity of neurotransmitter exocytosis. The result is a measurable decrease in the micro-contractions responsible for forehead lines, crow-s-feet, and perioral wrinkles. Because the octapeptide occupies a larger binding domain than its hexapeptide predecessor, its inhibitory potency per mole is substantially higher.
Efficacy Data
In controlled panel studies, a 3% SNAP-8 solution applied twice daily for 28 days outperformed equimolar Argireline by 30% in average wrinkle depth reduction measured via PRIMOS 3-D profilometry. Volunteers showed statistically significant smoothing of lateral canthal lines within 14 days. These results confirm the added two residues translate directly into improved clinical outcomes without increased irritation potential.
Formulation Guidelines
SNAP-8 is water-soluble and stable at pH 5.0-7.0. Recommended use level is 3-10% of a stock solution in the aqueous phase. It integrates well into serums, essences, ampoule concentrates, and lightweight emulsions. Avoid combining with strong oxidisers or heavy-metal catalysts that may degrade the methionine residue. For maximum penetration, pair with delivery systems such as liposomes or hyaluronic acid matrices. Heat exposure during manufacturing should remain below 40 degrees C to preserve biological activity.
Applications
- Anti-wrinkle serums targeting expression lines on forehead and eye contour
- Concentrated ampoule treatments for professional aesthetic clinics
- Eye creams designed as non-invasive alternatives to botulinum toxin
- Premium anti-aging night creams and intensive repair masks
- Combination products pairing SNAP-8 with Argireline for layered SNARE inhibition
Quality and Supply
TCS NEXUS S.L., based in Valencia, Spain, supplies Acetyl Octapeptide-3/1 at HPLC purity of 99% or higher. Each batch ships with a certificate of analysis covering identity (MS), purity (HPLC), peptide content, residual solvents, and microbial limits. We maintain stock for rapid dispatch across the European Union and accept orders from development-scale grams to multi-kilogram production volumes. Our regulatory team can provide documentation supporting EU Cosmetics Regulation (EC) No 1223/2009 compliance.
Storage
Store lyophilised powder at -20 degrees C in sealed, moisture-free containers. Reconstituted solutions should be kept at 2-8 degrees C and used within 6 months. Protect from direct UV light at all stages.
Frequently Asked Questions
What is the difference between SNAP-8 and Argireline?
SNAP-8 extends Argireline by two amino acids, increasing SNARE complex inhibition. At equivalent concentrations, SNAP-8 reduced wrinkle depth 30% more than Argireline in 28-day panel studies.
What concentration of SNAP-8 should I use?
Formulators typically incorporate 3-10% of a stock solution into the aqueous phase. Efficacy plateaus above 10%, making the 3-5% range most cost-effective for consumer products.
Is SNAP-8 compatible with other cosmetic peptides?
Yes. SNAP-8 pairs effectively with signal peptides like Matrixyl or carrier peptides like GHK-Cu. Maintain pH 5-7 and avoid strong oxidisers in the final formula.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
Do you provide COA documents for SNAP-8 Peptide Supplier Europe?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for SNAP-8 Peptide Supplier Europe?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for SNAP-8 Peptide Supplier Europe?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.