Myristoyl Pentapeptide-4: C14 Lipopeptide for Collagen I and III Stimulation
Myristoyl Pentapeptide-4 is a lipopeptide consisting of a five-amino-acid sequence conjugated to myristic acid (C14 fatty acid chain). This structural design follows the same lipopeptide engineering principle used in palmitoyl-conjugated peptides but employs the shorter C14 chain, which alters the compound partition coefficient and stratum corneum penetration kinetics compared to C16 palmitoyl analogs. The peptide sequence targets fibroblast receptors involved in extracellular matrix protein synthesis, specifically upregulating collagen type I and type III production.
Mechanism of Action: Dual Collagen Stimulation
The pentapeptide core sequence interacts with fibroblast growth factor receptors and integrin complexes on dermal fibroblast membranes, triggering intracellular signaling cascades that upregulate procollagen gene expression. Collagen type I provides tensile strength to the dermis–it constitutes approximately 80% of total dermal collagen. Collagen type III provides the flexible framework that supports elasticity and resilience, representing roughly 15% of dermal collagen content. By stimulating both types simultaneously, Myristoyl Pentapeptide-4 supports comprehensive dermal matrix renewal rather than favoring one structural component over another.
The Myristoyl Advantage: C14 Chain Characteristics
Myristic acid (C14:0) has a shorter carbon chain than palmitic acid (C16:0), resulting in a lower log P value and faster membrane transit kinetics. In practical formulation terms, myristoyl-conjugated peptides show slightly different partitioning behavior in emulsion systems and may achieve faster initial penetration through the stratum corneum lipid matrix. The C14 chain maintains oil solubility for lipid-phase incorporation while offering formulators an alternative penetration profile to palmitoyl variants. This distinction matters when optimizing delivery in specific vehicle types–anhydrous oils, W/O emulsions, or lipid nanoparticle systems.
Formulation Parameters
Myristoyl Pentapeptide-4 is oil-soluble due to the C14 fatty acid conjugation. Recommended use levels range from 50-200 ppm in finished cosmetic formulations. Incorporate into the oil phase of emulsions at temperatures below 45 degrees Celsius to preserve peptide bond integrity. Compatible with standard cosmetic emulsifiers, silicone fluids, and natural oils. Avoid strong oxidizing conditions and maintain formulation pH in the mildly acidic range for optimal stability during shelf life.
Application Categories
- Anti-wrinkle night creams and intensive repair serums
- Eye contour treatments targeting fine lines and crepiness
- Oil-based facial serums and dry oil formulations
- Neck and decollete firming treatments
- Professional-grade anti-aging concentrates for clinic use
Formulation Synergies
Combine Myristoyl Pentapeptide-4 with retinol or bakuchiol for complementary collagen stimulation through different receptor pathways. Pairing with Tripeptide-10 Citrulline provides both collagen production upregulation and fibril organization in a single formula. For comprehensive anti-aging stacks, add a copper peptide (GHK-Cu) to support matrix metalloproteinase regulation alongside the direct collagen synthesis benefits. Antioxidant co-ingredients such as tocopherol and astaxanthin protect the newly synthesized collagen from oxidative cross-linking damage.
Quality and Ordering
TCS NEXUS S.L. produces Myristoyl Pentapeptide-4 from our warehouse in Valencia, Spain. Minimum order quantity is 1 g for formulation evaluation and 100 g for production scale. EU delivery completes within 5-7 business days. Full analytical documentation accompanies each lot including HPLC purity data, mass spectrometry identity confirmation, and microbiological testing certificates.
Frequently Asked Questions
How does Myristoyl Pentapeptide-4 compare to Palmitoyl Pentapeptide-4?
Both share the same pentapeptide core sequence but differ in their fatty acid chain. The myristoyl (C14) version has a shorter chain than the palmitoyl (C16), resulting in different partition coefficients and penetration kinetics. Formulators select between them based on vehicle compatibility and desired delivery profile.
What is the recommended concentration range?
Use 50-200 ppm in finished cosmetic products. Start at 100 ppm for standard anti-aging formulations and adjust based on efficacy testing in your specific vehicle system.
Can this peptide be used in water-based formulations?
Myristoyl Pentapeptide-4 is oil-soluble and should be incorporated into lipid phases. For aqueous serums, use an appropriate solubilizer or consider a water-soluble peptide alternative from our catalog.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
Do you provide COA documents for Myristoyl Pentapeptide-4 Supplier?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for Myristoyl Pentapeptide-4 Supplier?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for Myristoyl Pentapeptide-4 Supplier?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.