Decapeptide-4: KGF-Mimetic Peptide for Intensive Epidermal Repair
Decapeptide-4 is a biomimetic decapeptide engineered to reproduce the signaling activity of keratinocyte growth factor (KGF/FGF-7). With a molecular weight of approximately 1100 g/mol, this custom-synthesis peptide targets the FGFR2-IIIb receptor on basal keratinocytes, triggering proliferation and accelerated epidermal turnover. TCS NEXUS S.L. supplies research-grade and cosmetic-grade Decapeptide-4 from our warehouse in Valencia, Spain. Active at low ppm concentrations, it is particularly suited to post-procedure recovery serums and intensive wound-care-adjacent formulations where rapid barrier restoration is required.
Mechanism of Action and Efficacy Data
Decapeptide-4 binds the FGFR2-IIIb receptor expressed on keratinocytes, activating the RAS-MAPK and PI3K-AKT signaling cascades. This drives keratinocyte migration from the basal layer and stimulates mitotic division in the stratum basale, accelerating re-epithelialization.
In vitro testing on primary human keratinocyte cultures demonstrated a 73% increase in cell proliferation at 20 ppm versus untreated controls over 72 hours. Scratch assay wound models showed a 38% improvement in closure rate at 10 ppm compared to vehicle alone, with statistical significance (p < 0.01). The peptide shows dose-dependent activity between 5-50 ppm, with a plateau observed above 40 ppm. Unlike full-length recombinant KGF, Decapeptide-4 maintains stability in aqueous formulations at pH 5.0-7.0 without requiring cold-chain storage. This makes it practical for finished cosmetic products targeting skin repair without the logistical burden of biologics.
Formulation Guide
Decapeptide-4 is water-soluble and should be incorporated into the aqueous phase of emulsions or directly into water-based serums. Add at temperatures below 45C to preserve peptide integrity — post-emulsification addition during the cool-down phase is recommended. The effective use level is 5-50 ppm (0.0005-0.005%). Maintain final formulation pH between 5.0 and 7.0; activity drops significantly below pH 4.5 due to protonation of key histidine residues.
For post-procedure recovery serums, pair with Copper Tripeptide-1 at 50-100 ppm for synergistic wound repair activity. In barrier-repair formulations, combine with ceramide NP (0.5-1%) and cholesterol (0.3%) to support both signaling and structural recovery. Avoid co-formulation with strong oxidizers (hydrogen peroxide, benzoyl peroxide) which degrade the peptide bond. Compatible with hyaluronic acid, niacinamide, and panthenol at standard use levels.
Frequently Asked Questions
What is the difference between Decapeptide-4 and recombinant KGF?
Decapeptide-4 is a short synthetic peptide (10 amino acids, ~1100 Da) that mimics the receptor-binding domain of full-length KGF (28 kDa). It targets the same FGFR2-IIIb receptor but offers superior formulation stability at ambient temperatures and does not require cold-chain logistics. Cost per effective dose is substantially lower than recombinant protein.
Can Decapeptide-4 be used in post-laser treatment products?
Yes. The keratinocyte proliferation data (73% increase at 20 ppm) supports its use in post-ablative and post-fractional laser recovery formulations. Formulate in a simple aqueous vehicle at pH 5.5-6.5 with hyaluronic acid for hydration support. Apply starting 24-48 hours post-procedure per dermatologist guidance.
What is the minimum order quantity?
TCS NEXUS S.L. offers 1 g evaluation samples for formulation testing and R&D. Production orders start at 100 g. EU delivery within 5-7 business days from our Valencia warehouse.
Is Decapeptide-4 COSMOS approved?
Decapeptide-4 supplied by TCS NEXUS S.L. is sourced from COSMOS-certified production. It is suitable for inclusion in natural and organic certified formulations when used within the approved framework.
How does Decapeptide-4 compare to Acetyl Decapeptide-3?
Acetyl Decapeptide-3 mimics IGF-1 signaling and primarily targets dermal fibroblasts and collagen synthesis. Decapeptide-4 mimics KGF and targets epidermal keratinocytes. They address different layers of the skin and can be combined in multi-target anti-aging or repair formulations for simultaneous dermal and epidermal activity.
Product Specifications
| Parameter | Specification |
|---|---|
| INCI Name | Decapeptide-4 |
| CAS Number | Custom synthesis peptide |
| Molecular Weight | ~1100 g/mol |
| Appearance | White to off-white powder |
| Solubility | Water soluble |
| Recommended Use Level | 5-50 ppm |
| pH Range | 5.0-7.0 |
| Processing Temperature | Below 45C |
| MOQ | 1 g (evaluation), 100 g (production) |
| EU Delivery | 5-7 business days |
Related Peptides
- Acetyl Decapeptide-3 — IGF-1 mimetic for dermal fibroblast stimulation and collagen synthesis
- Copper Tripeptide-1 — Multi-target wound repair peptide with MMP modulation and angiogenesis support
Order Decapeptide-4 from TCS NEXUS S.L.
Request a 1 g evaluation sample or place a production order (MOQ 100 g) directly through our site. All orders ship from Valencia, Spain with EU delivery in 5-7 business days. Technical documentation including CoA, MSDS, and formulation guidance available on request. Contact our peptide specialists for custom synthesis inquiries or bulk pricing.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
Do you provide COA documents for Decapeptide-4 Supplier Europe?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for Decapeptide-4 Supplier Europe?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for Decapeptide-4 Supplier Europe?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.