Biotinoyl Tripeptide-1 is a biotin-peptide conjugate engineered to strengthen hair follicle anchoring and promote lash and brow growth. With a molecular weight of approximately 600 g/mol and CAS number 299157-54-3, this ingredient pairs the follicle-targeting properties of biotin with a tripeptide sequence that stimulates keratinocyte matrix proteins. TCS NEXUS S.L. supplies Biotinoyl Tripeptide-1 from our warehouse in Valencia, Spain at purity levels exceeding 98 percent, certified. EU delivery takes 5-7 business days with evaluation samples from 1 g and production orders from 100 g.
Mechanism of Action and Clinical Evidence
The biotin moiety in Biotinoyl Tripeptide-1 serves as a homing group. Biotin receptors are concentrated on hair follicle cells, so the conjugate preferentially accumulates where it is needed most. Once localized, the tripeptide portion stimulates synthesis of laminin-5 and collagen IV in the dermal papilla, two matrix proteins that anchor the hair bulb within the follicle sheath. Stronger anchoring means less premature shedding during the anagen-to-catagen transition.
In a controlled 3-month lash study with 25 subjects, topical application of Biotinoyl Tripeptide-1 increased lash density by 25 percent and lash length by 36 percent versus baseline measurements. These results reflect both improved retention of existing lashes and stimulation of new follicle cycling. The dual mechanism, structural reinforcement plus growth signaling, distinguishes this peptide from prostaglandin-analog lash products that carry more regulatory complexity. Because the tripeptide backbone also upregulates keratin expression, treated lashes and brows appear thicker and more resilient to mechanical stress from curling or brushing.
Formulation Guide
Biotinoyl Tripeptide-1 is water soluble. Dissolve in deionized water at a stock concentration of 2000-5000 ppm, then dilute to the target use level: 50-200 ppm for lash and brow serums, 100-500 ppm for scalp and hair treatments where higher concentrations compensate for the larger application area. Add during the cool-down phase at temperatures below 40 degrees Celsius. Maintain finished product pH between 4.5 and 6.5 for optimal stability. This peptide is compatible with panthenol, caffeine, saw palmetto extract, and common preservative systems. Avoid strongly alkaline conditions above pH 8 which can hydrolyze the biotin-peptide bond. Typical finished formats include lash serums with brush applicators, brow conditioning gels, scalp tonics, and leave-in hair treatments.
Frequently Asked Questions
What does Biotinoyl Tripeptide-1 do for lashes?
Biotinoyl Tripeptide-1 strengthens the anchoring of lash follicles by stimulating laminin-5 and collagen IV synthesis in the dermal papilla. In a 3-month clinical study with 25 subjects, lash density increased 25 percent and lash length increased 36 percent compared to baseline.
How is Biotinoyl Tripeptide-1 different from pure biotin?
Pure biotin is a vitamin that supports keratin metabolism but has limited topical penetration. Biotinoyl Tripeptide-1 conjugates biotin to a tripeptide that actively stimulates matrix protein production at the hair follicle. The biotin moiety targets the peptide to follicle cells, while the tripeptide delivers the structural reinforcement.
What concentration should I use in a lash serum?
For lash and brow serums, use 50-200 ppm. For scalp and hair products, use 100-500 ppm. The higher range in hair products compensates for greater surface area and dilution from styling routines.
Is Biotinoyl Tripeptide-1 safe for sensitive eyes?
Biotinoyl Tripeptide-1 has a strong safety profile at recommended use levels. It is not a prostaglandin analog and does not carry the periorbital fat loss or iris color change risks associated with that class of actives. Standard ophthalmological compatibility testing is still recommended for any lash product.
Specifications
| Parameter | Value |
|---|---|
| INCI Name | Biotinoyl Tripeptide-1 |
| CAS Number | 299157-54-3 |
| Molecular Weight | ~600 g/mol |
| Purity | Greater than 98% |
| Solubility | Water soluble |
| Recommended pH | 4.5 – 6.5 |
| Use Level (Lash/Brow) | 50 – 200 ppm |
| Use Level (Hair/Scalp) | 100 – 500 ppm |
| Processing Temperature | Below 40 degrees C |
| MOQ (Evaluation) | 1 g |
| MOQ (Production) | 100 g |
| EU Delivery | 5 – 7 business days |
Related Peptides
- Copper Tripeptide-1 – scalp repair and follicle microenvironment support
- Acetyl Tetrapeptide-9 – lumican-stimulating peptide for dermal remodeling
Add Biotinoyl Tripeptide-1 to your hair care line. Contact TCS NEXUS S.L. for samples and bulk pricing. We ship from Valencia, Spain with 5-7 day delivery across Europe. Start with a 1 g evaluation sample or move directly to 100 g production quantities.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
Do you provide COA documents for Biotinoyl Tripeptide-1 Supplier Europe?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for Biotinoyl Tripeptide-1 Supplier Europe?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for Biotinoyl Tripeptide-1 Supplier Europe?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.