Acetyl Tetrapeptide-9 is a lumican-stimulating peptide engineered to improve collagen fibril organization in the dermis. With a molecular weight of approximately 530 g/mol and CAS number 928006-50-2, this tetrapeptide targets a specific proteoglycan pathway that most collagen-boosting actives miss entirely. TCS NEXUS S.L. supplies Acetyl Tetrapeptide-9 from our warehouse in Valencia, Spain at purity levels exceeding 98 percent, certified. EU delivery takes 5-7 business days with evaluation quantities starting at 1 g and production orders from 100 g.
Mechanism of Action and Efficacy Data
Collagen quantity alone does not determine skin firmness. The organization of collagen fibrils into ordered bundles is equally critical, and that process depends on lumican, a small leucine-rich proteoglycan that acts as a molecular scaffold during fibrillogenesis. Acetyl Tetrapeptide-9 stimulates lumican synthesis in dermal fibroblasts, leading to better collagen fibril alignment and tighter dermal architecture.
In fibroblast culture studies at 50 ppm, Acetyl Tetrapeptide-9 increased lumican expression by 51 percent compared to untreated controls. The same treatment condition showed collagen I synthesis elevated by 31 percent. These dual effects, more collagen and better collagen organization, translate to measurable improvements in skin firmness and elasticity. The acetylated N-terminus protects against enzymatic cleavage in the stratum corneum, allowing more intact peptide to reach target cells in the upper dermis. Because lumican deficiency is a hallmark of photoaged skin, this peptide addresses a root cause of dermal laxity rather than simply adding more collagen to a disorganized matrix.
Formulation Guide
Acetyl Tetrapeptide-9 is water soluble. Dissolve in deionized water or a compatible aqueous phase at a stock concentration of 1000-5000 ppm, then dilute to the target use level of 20-100 ppm in the finished product. Add during the cool-down phase at temperatures below 45 degrees Celsius. The optimal pH range for stability and efficacy is 5.0 to 7.0. This peptide pairs well with hyaluronic acid, ceramides, and other barrier-repair ingredients. Avoid combining with strong acids or oxidizing agents that could cleave the acetyl group. Primary applications include firming serums, anti-aging moisturizers, neck and decollete treatments, and any product claiming dermal remodeling or collagen organization benefits.
Frequently Asked Questions
What does Acetyl Tetrapeptide-9 do in skincare?
Acetyl Tetrapeptide-9 stimulates lumican synthesis, a proteoglycan that organizes collagen fibrils into ordered bundles. This improves dermal architecture, resulting in firmer and more elastic skin. It also increases collagen I production by 31 percent at 50 ppm in fibroblast cultures.
What is the difference between Acetyl Tetrapeptide-9 and collagen peptides?
Collagen peptides provide amino acid building blocks. Acetyl Tetrapeptide-9 works differently by stimulating lumican, which organizes how collagen fibrils assemble. It addresses fibril architecture rather than raw collagen quantity, making it complementary to collagen-boosting ingredients.
What concentration of Acetyl Tetrapeptide-9 should I use?
Use 20-100 ppm in finished formulations. The key efficacy data was generated at 50 ppm, which is a practical mid-range concentration for most serum and cream formats.
Can I combine Acetyl Tetrapeptide-9 with vitamin C?
Acetyl Tetrapeptide-9 is stable between pH 5.0 and 7.0. Low-pH ascorbic acid formulations below pH 3.5 may compromise the acetyl group. Use a stabilized vitamin C derivative at a compatible pH, or formulate them in separate products for layered application.
Specifications
| Parameter | Value |
|---|---|
| INCI Name | Acetyl Tetrapeptide-9 |
| CAS Number | 928006-50-2 |
| Molecular Weight | ~530 g/mol |
| Purity | Greater than 98% |
| Solubility | Water soluble |
| Recommended pH | 5.0 – 7.0 |
| Use Level | 20 – 100 ppm |
| Processing Temperature | Below 45 degrees C |
| MOQ (Evaluation) | 1 g |
| MOQ (Production) | 100 g |
| EU Delivery | 5 – 7 business days |
Related Peptides
- Copper Tripeptide-1 – matrix metalloproteinase modulator for dermal remodeling
- Acetyl Decapeptide-3 – biomimetic growth factor peptide for fibroblast proliferation
Source Acetyl Tetrapeptide-9 for your next formulation. Contact TCS NEXUS S.L. for pricing and sample availability. We ship from Valencia, Spain with 5-7 day delivery throughout Europe. Start with a 1 g evaluation sample or order 100 g for production runs.
Technical Fit and Sourcing Focus
Acetyl Tetrapeptide-9 strengthens the matrix and firmness branch of the portfolio for buyers comparing structure-support and anti-aging peptides.
Best-Fit Applications
- Firming and structure-support skincare formulas
- Premium anti-aging projects emphasizing skin density
- Matrix-oriented peptide sourcing comparisons
How This Page Fits the Core Peptide Cluster: This page is intentionally linked with adjacent anti-aging, brightening, repair, and matrix-support peptides so crawlers can follow a tighter topical path across the site.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
Why is Acetyl Tetrapeptide-9 part of the core indexing push?
It reinforces the firming and structure-support branch of the site, helping the peptide cluster read as a coherent anti-aging portfolio rather than a loose set of isolated pages.
Can Acetyl Tetrapeptide-9 be reviewed with other matrix-support actives?
Yes. It is a good fit for side-by-side sourcing review with collagen, firmness, and matrix-oriented peptides already prioritized on the site.
Do you provide COA documents for Acetyl Tetrapeptide-9 Supplier Europe?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for Acetyl Tetrapeptide-9 Supplier Europe?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for Acetyl Tetrapeptide-9 Supplier Europe?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.