Myristoyl Hexapeptide-16: Scalp-Care Peptide for Hair Follicle Anchoring
Myristoyl Hexapeptide-16 (CAS 959610-54-9) is a lipopeptide designed for scalp and hair care applications, specifically targeting the structural proteins responsible for hair follicle anchoring within the dermal papilla. By strengthening the attachment between the hair fiber root sheath and surrounding connective tissue, this peptide reduces hair breakage and premature shedding. TCS NEXUS S.L. produces Myristoyl Hexapeptide-16 from our warehouse in Valencia, Spain.
Mechanism of Action
Hair follicle anchoring depends on a network of adhesion proteins connecting the inner root sheath to the outer root sheath and surrounding dermal connective tissue. Myristoyl Hexapeptide-16 penetrates the scalp epidermis via its myristoyl (C14) lipid chain and reaches the follicular bulge region where stem cells and anchoring structures reside. The hexapeptide sequence stimulates expression of desmoglein-4 and plakoglobin, two critical desmosomal proteins that maintain structural integrity at the root sheath junction. Additionally, the peptide upregulates fibronectin and tenascin-C production in the perifollicular extracellular matrix, reinforcing the connective tissue scaffold that holds each follicle in place during the mechanical stress of brushing and styling.
Clinical Evidence
In a 3-month clinical study, Myristoyl Hexapeptide-16 at 200ppm in a leave-on scalp serum reduced hair breakage by 30% compared to placebo, measured by the combing resistance and fiber fragment collection method. Pull-test evaluations showed a 24% improvement in hair anchoring force, indicating stronger follicular attachment. Trichoscopic analysis revealed increased anagen-to-telogen ratio and improved perifollicular vascularization scores. Participants reported reduced hair fall during washing and styling, with visible improvements in overall hair density perception from week 8 onward.
Formulation Guidelines
Myristoyl Hexapeptide-16 is effective at 100-300ppm in finished scalp and hair care products. The amphiphilic nature of the lipopeptide allows incorporation into both aqueous scalp serums and oil-based scalp treatments. It performs optimally in leave-on formulations that maximize contact time with the scalp surface. Cosmetic chemists developing hair loss prevention lines frequently combine Myristoyl Hexapeptide-16 with Biotinoyl Tripeptide-1 for anchoring plus growth stimulation, or with caffeine and saw palmetto extract for multi-pathway hair density support. The peptide is stable at pH 4.5-6.5 and compatible with standard surfactant systems in rinse-off products, though leave-on applications deliver superior results.
Product Applications
- Anti-hair-loss scalp serums and tonics
- Hair strengthening leave-on treatments and scalp ampoules
- Post-partum hair recovery formulations
- Shampoos and conditioners for fragile, breakage-prone hair
- Multi-peptide scalp protocols combined with growth-stimulating peptides
Quality and European Manufacturing
As a specialist Myristoyl Hexapeptide-16 supplier in Europe, TCS NEXUS S.L. provides this scalp-care peptide with full quality documentation from our warehouse in Valencia, Spain. Each batch undergoes HPLC purity verification, mass spectrometry identity confirmation, and microbiological safety testing. Complete documentation packages include Certificate of Analysis, MSDS, and regulatory documentation for brands positioning in the natural hair care segment.
How to Order
Evaluation samples start from 1g for preliminary formulation work and scalp compatibility testing. Production minimum order quantities begin at 100g with tiered pricing available for larger recurring orders. EU-wide delivery is completed within 3-5 business days with appropriate storage documentation. Contact our peptide specialists for technical support on scalp delivery optimization and concentration recommendations for your hair care product development program.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
Do you provide COA documents for Myristoyl Hexapeptide-16 (CAS 959610-54-9) EU?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for Myristoyl Hexapeptide-16 (CAS 959610-54-9) EU?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for Myristoyl Hexapeptide-16 (CAS 959610-54-9) EU?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.