Hexapeptide-11 – CAS 161258-30-6
Hexapeptide-11 is a six-amino-acid peptide originally derived from Saccharomyces yeast fermentation. With a molecular weight of approximately 700 Da and CAS number 161258-30-6, this peptide targets skin elasticity and texture refinement through mechanisms distinct from the more common collagen-signalling or neuromuscular peptide families. Its yeast-derived origin provides a biotechnology-sourced ingredient narrative that resonates with clean-beauty and fermentation-forward cosmetic brands.
Mechanism of Action
Hexapeptide-11 stimulates keratinocyte proliferation and upregulates heat shock protein expression in dermal fibroblasts. These heat shock proteins act as molecular chaperones, stabilising collagen and elastin folding under environmental stress. The peptide also promotes laminin-5 production at the dermal-epidermal junction, strengthening the anchoring system that keeps the epidermis firmly attached to the dermis. This combination of structural reinforcement and stress-response activation translates into measurably firmer, more resilient skin with refined pore appearance.
Clinical Efficacy
In a 56-day in vivo panel study, subjects applying a formulation containing 0.005% Hexapeptide-11 showed a 12% improvement in skin elasticity measured by cutometry (R2 parameter). Participants also reported visible pore refinement and smoother texture across the cheek and forehead zones. These results were achieved at an exceptionally low use level, demonstrating the high biological potency of this yeast-derived sequence.
Formulation Guidelines
Incorporate Hexapeptide-11 at 0.001-0.01% in the aqueous phase. The peptide dissolves in water and dilute glycol systems. Stable across pH 4.5-7.0 and processing temperatures up to 40 degrees C. It pairs well with hyaluronic acid, ceramides, and fermentation-derived actives like galactomyces filtrate. Avoid combining with high concentrations of anionic surfactants that may denature the peptide at low pH. For maximum consumer appeal, position alongside other biotechnology-sourced ingredients in fermentation-themed product lines.
Applications
- Firming serums and creams for loss of elasticity in mature skin
- Pore-refining treatments targeting rough texture on cheeks and T-zone
- Fermentation-inspired skincare lines leveraging yeast-derived actives
- Neck and jawline contouring products for sagging skin
- Lightweight gel moisturisers for combination skin seeking firmness without heaviness
Quality and Supply from TCS NEXUS S.L.
TCS NEXUS S.L. supplies Hexapeptide-11 from Valencia, Spain with HPLC purity of 98% minimum. Each batch ships with a certificate of analysis covering identity (mass spectrometry), purity (HPLC), peptide content, amino acid composition, and microbial limits. We support order sizes from research-grade quantities to multi-kilogram production volumes with rapid European dispatch. Regulatory documentation aligned with EU Cosmetics Regulation (EC) No 1223/2009 is available on request.
Storage
Store lyophilised powder at -20 degrees C in sealed, moisture-free containers. Reconstituted solutions should be kept at 2-8 degrees C and used within 6 months. Protect from direct UV light to prevent degradation.
Frequently Asked Questions
What makes Hexapeptide-11 different from collagen peptides?
Hexapeptide-11 is derived from Saccharomyces yeast and works primarily through heat shock protein activation and laminin-5 upregulation, whereas collagen peptides typically signal fibroblasts to produce collagen directly. This makes Hexapeptide-11 better suited for elasticity and texture improvement.
What concentration of Hexapeptide-11 is effective?
Clinical data shows measurable elasticity improvement at just 0.005%. The recommended formulation range is 0.001-0.01%, making it one of the most potent cosmetic peptides by weight.
Is Hexapeptide-11 suitable for sensitive skin formulations?
Yes. The extremely low use level and yeast-derived origin result in excellent tolerability. No irritation or sensitisation was reported in panel studies at recommended concentrations.
Technical Fit and Sourcing Focus
Hexapeptide-11 gives the site another resilience and skin-conditioning peptide page that supports premium anti-aging and barrier-oriented projects.
Best-Fit Applications
- Skin-conditioning and resilience-focused formulations
- Anti-aging concepts positioned around daily defense
- Premium peptide blends with broader supportive positioning
How This Page Fits the Core Peptide Cluster: This page is intentionally linked with adjacent anti-aging, brightening, repair, and matrix-support peptides so crawlers can follow a tighter topical path across the site.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
What role does Hexapeptide-11 play in the core page strategy?
It supports the site’s peptide topical breadth with another skin-conditioning and premium-care angle while staying tightly aligned with the current domain focus.
Can Hexapeptide-11 be sourced as part of a broader peptide bundle?
Yes. Customers can review it together with adjacent anti-aging, scalp-care, and resilience-oriented peptide options before placing commercial orders.
Do you provide COA documents for Hexapeptide-11 Supplier Europe?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for Hexapeptide-11 Supplier Europe?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for Hexapeptide-11 Supplier Europe?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.