Dipeptide-2: Anti-Puffiness Eye Contour Peptide for Professional Formulations
If you develop eye contour products, Dipeptide-2 is one of the few peptides with a specific, measurable mechanism for reducing periorbital puffiness. This Val-Trp dipeptide (CAS 24587-37-9, MW 202.21 g/mol) promotes lymphatic drainage in the under-eye area and strengthens capillary walls, addressing the two primary causes of eye bags and fluid retention. At TCS NEXUS S.L. in Valencia, Spain, we supply Dipeptide-2 at 98%+ purity with EU delivery in 5-7 business days. Start with a 1 g evaluation sample at no cost for qualified formulators.
Mechanism of Action and Efficacy Data
Periorbital puffiness results from impaired lymphatic circulation and increased capillary permeability in the tissue surrounding the eye. Fluid leaks from weakened capillaries into the interstitial space, and sluggish lymphatic flow fails to clear it efficiently. The result is visible swelling, particularly in the morning or after periods of recumbence.
Dipeptide-2 acts on both sides of this problem. It stimulates lymphatic endothelial cell contraction, improving the rate at which accumulated fluid is drained from periorbital tissue. Simultaneously, it reduces vascular permeability by supporting tight junctions between capillary endothelial cells, limiting further fluid extravasation. This dual mechanism distinguishes it from caffeine or other vasoconstrictive agents that only address one component.
In a 56-day controlled study with 20 subjects, a formulation containing 2% Dipeptide-2 solution reduced under-eye puffiness scores by 32% and dark circle intensity by 21% versus baseline, assessed by trained evaluators using standardized photography. These results were statistically significant and visible in before-and-after imaging. The peptide is frequently combined with palmitoyl tetrapeptide-7 and hesperidin methyl chalcone in commercial eye-contour systems marketed under the Eyeliss trade name.
Formulation Guide for Eye Contour Products
Dipeptide-2 is water-soluble and should be incorporated during the cool-down phase of your emulsion process, below 40 degrees Celsius. The active is effective at low concentrations: 50-500 ppm (0.005-0.05%) of pure peptide, or 1-3% of a typical active solution, depending on your supplier concentration.
Maintain formulation pH between 5.0 and 7.0 for optimal stability and skin compatibility in the delicate eye area. The peptide is compatible with a wide range of cosmetic actives and pairs particularly well with caffeine (for immediate vasoconstrictive effect), vitamin K (for dark circle reduction), hesperidin (for capillary strengthening), and Acetyl Tetrapeptide-9 for collagen matrix support.
For a complete eye contour serum, consider combining Dipeptide-2 with a lightweight gel or low-viscosity emulsion base. Avoid heavy occlusive systems around the eyes, as they can trap fluid and counteract the drainage benefits of the peptide. Standard preservative systems are compatible; no special precautions are needed beyond temperature control during addition.
Frequently Asked Questions
What is Dipeptide-2 made of?
Dipeptide-2 is a synthetic dipeptide composed of valine and tryptophan (Val-Trp). Its molecular weight is 202.21 g/mol and it is registered under CAS 24587-37-9.
How does Dipeptide-2 differ from other eye peptides?
Most eye-area peptides target wrinkles or firmness. Dipeptide-2 specifically addresses puffiness and fluid retention by promoting lymphatic drainage and reducing capillary permeability. It works on a different mechanism than anti-wrinkle peptides like acetyl hexapeptide-8.
Can I use Dipeptide-2 in a full-face product?
Yes, though its primary benefits target the periorbital area where lymphatic drainage and capillary fragility are most relevant. It will not cause adverse effects on other facial zones, but the efficacy data is specific to the eye contour.
What concentration should I use in an eye serum?
Use 50-500 ppm of pure peptide (0.005-0.05%) or 1-3% of a standard active solution. The 56-day study showing 32% puffiness reduction used a 2% solution concentration.
What is the minimum order for Dipeptide-2?
Evaluation quantities start at 1 g. Production orders begin at 100 g. Free samples are available for qualified formulators and contract manufacturers in the EU. Contact our team in Valencia for pricing and lead times.
Product Specifications
| Parameter | Specification |
|---|---|
| INCI Name | Dipeptide-2 |
| Sequence | Val-Trp |
| CAS Number | 24587-37-9 |
| Molecular Weight | 202.21 g/mol |
| Purity | 98%+ (HPLC) |
| Appearance | White to off-white powder |
| Solubility | Water-soluble |
| Recommended pH Range | 5.0 – 7.0 |
| Use Level | 50-500 ppm pure peptide, or 1-3% active solution |
| Processing Temperature | Add below 40 degrees C |
| MOQ | 1 g (evaluation), 100 g (production) |
| Delivery | EU 5-7 business days from Valencia, Spain |
Related Eye and Anti-Aging Peptides
- Copper Tripeptide-1 – GHK-Cu complex for wound healing, collagen stimulation, and anti-aging repair.
- Dipeptide Diaminobutyroyl Benzylamide Diacetate – Expression line peptide for targeted muscle relaxation around the eyes and forehead.
- Acetyl Dipeptide-1 Cetyl Ester – Comfort and firming peptide for sensitive skin and anti-aging formulations.
Order Dipeptide-2 from TCS NEXUS S.L.
Get started with an evaluation sample or place your production order today. Our technical team in Valencia, Spain provides formulation support, certificates of analysis, and full regulatory documentation for EU and international markets. Free samples for qualified formulators. EU delivery in 5-7 business days. Reach out now to discuss your eye contour project.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
Do you provide COA documents for Dipeptide-2 Eye Peptide Supplier Europe?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for Dipeptide-2 Eye Peptide Supplier Europe?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for Dipeptide-2 Eye Peptide Supplier Europe?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.