Acetyl Decapeptide-3 is a biomimetic growth factor peptide designed to replicate endogenous signaling cascades that drive dermal repair. With a molecular weight of approximately 1200 g/mol and CAS number 935288-50-9, this decapeptide triggers fibroblast activation without relying on recombinant growth factors. TCS NEXUS S.L. supplies Acetyl Decapeptide-3 from our warehouse in Valencia, Spain at purity levels exceeding 98 percent. EU delivery takes 5-7 business days with a minimum order of 1 g for evaluation or 100 g for production batches.
Mechanism of Action and Clinical Data
Acetyl Decapeptide-3 mimics growth factor signaling at the receptor level, stimulating cell proliferation and matrix protein synthesis in dermal fibroblasts. The acetyl group on the N-terminus improves membrane permeability and protects against aminopeptidase degradation, extending the active half-life within the skin.
In controlled cell culture studies, Acetyl Decapeptide-3 at 10 ppm increased fibroblast proliferation by 62 percent versus untreated controls over a 48-hour incubation period. This proliferative response correlates with upregulated expression of collagen I, collagen III, and fibronectin, the structural proteins responsible for dermal volume and tensile strength. The peptide operates through a dose-dependent curve, showing measurable activity starting at 5 ppm and plateauing near 50 ppm in most in vitro models. Because it functions as a signaling molecule rather than a structural building block, effective concentrations remain low, keeping raw material costs manageable even at commercial scale.
Formulation Guide
Acetyl Decapeptide-3 is water soluble. Prepare a stock solution at 500-1000 ppm in deionized water or a suitable aqueous phase, then dilute to the target use level of 5-50 ppm in your final formulation. Add during cool-down at temperatures below 45 degrees Celsius to preserve peptide integrity. Maintain the finished product pH between 5.0 and 7.0. This peptide is compatible with most cosmetic ingredients including hyaluronic acid, niacinamide, and common emulsifiers. Avoid direct combination with strong oxidizers or systems below pH 4.5. Target applications include anti-aging serums, regenerative eye creams, and intensive overnight masks where fibroblast stimulation drives the product claim.
Frequently Asked Questions
What is Acetyl Decapeptide-3 used for in cosmetics?
Acetyl Decapeptide-3 is used in anti-aging serums, eye creams, and regenerative masks. It mimics growth factor signaling to stimulate fibroblast proliferation and boost synthesis of collagen and other extracellular matrix proteins.
What is the recommended use level for Acetyl Decapeptide-3?
The recommended use level is 5-50 ppm in the final formulation. In vitro data shows measurable activity at 10 ppm, where fibroblast proliferation increased 62 percent over controls in a 48-hour assay.
Is Acetyl Decapeptide-3 water soluble?
Yes. Acetyl Decapeptide-3 dissolves readily in water and aqueous phases. Prepare a concentrated stock solution and add it during the cool-down phase below 45 degrees Celsius.
What certifications does TCS NEXUS hold for this peptide?
Every batch ships with a Certificate of Analysis confirming purity above 98 percent.
Specifications
| Parameter | Value |
|---|---|
| INCI Name | Acetyl Decapeptide-3 |
| CAS Number | 935288-50-9 |
| Molecular Weight | ~1200 g/mol |
| Purity | Greater than 98% |
| Solubility | Water soluble |
| Recommended pH | 5.0 – 7.0 |
| Use Level | 5 – 50 ppm |
| Processing Temperature | Below 45 degrees C |
| MOQ (Evaluation) | 1 g |
| MOQ (Production) | 100 g |
| EU Delivery | 5 – 7 business days |
Related Peptides
- Copper Tripeptide-1 – matrix remodeling and wound repair signaling
- Decapeptide-4 – melanogenesis regulation peptide
- Acetyl Tetrapeptide-9 – lumican-stimulating collagen organization peptide
Ready to formulate with Acetyl Decapeptide-3? Contact TCS NEXUS S.L. for a sample or production quote. We ship from Valencia, Spain with 5-7 day delivery across Europe. Request your evaluation sample starting at 1 g or scale directly to 100 g production quantities.
Technical Fit and Sourcing Focus
Acetyl Decapeptide-3 reinforces the site’s growth-factor-inspired peptide branch for advanced repair, renewal, and premium regeneration concepts.
Best-Fit Applications
- Advanced repair and renewal formulations
- Premium peptide programs positioned around regeneration
- Comparative sourcing for high-value repair-support actives
How This Page Fits the Core Peptide Cluster: This page is intentionally linked with adjacent anti-aging, brightening, repair, and matrix-support peptides so crawlers can follow a tighter topical path across the site.
Technical Support and Samples
Request COA documents, sample availability, or support for custom synthesis.
Frequently Asked Questions
Why is Acetyl Decapeptide-3 useful in the priority product cluster?
It gives the site a stronger repair and regeneration branch, which complements the copper peptide pages and makes the overall peptide graph more coherent.
Can Acetyl Decapeptide-3 be evaluated for premium repair-oriented projects?
Yes. TCS can support documentation review, sample confirmation, and sourcing discussions for advanced regeneration-focused development work.
Do you provide COA documents for Acetyl Decapeptide-3 Supplier Europe?
Yes. Each lot can be supplied with a Certificate of Analysis, HPLC purity data, and relevant quality-control results for technical review.
Are samples available for Acetyl Decapeptide-3 Supplier Europe?
Yes. Sample availability can be confirmed for formulation screening and internal evaluation before a commercial order is placed.
What is the delivery lead time for Acetyl Decapeptide-3 Supplier Europe?
For stocked material in Valencia, EU delivery is typically 5 to 7 business days. Final timing depends on destination and requested volume.
Do you also support custom synthesis and technical inquiries?
Yes. The team can help with custom synthesis, raw-material selection, technical documentation, and supply planning.