Acetyl Tetrapeptide-5: Peptido Periorbital para Bolsas y Ojeras
Acetyl Tetrapeptide-5 (INCI: Acetyl Tetrapeptide-5, CAS 820959-17-9) es un peptido acetilado de cuatro aminoacidos con un peso molecular de 492.53 g/mol. Su secuencia – Ac-beta-Ala-His-Ser-His – fue disenada para abordar las dos causas principales de las preocupaciones del contorno de ojos: la acumulacion de liquidos (bolsas) y la decoloracion de origen vascular (ojeras). Este peptido pertenece a la categoria tipo Eyeseryl y se ha convertido en un activo fundamental en formulaciones profesionales de cuidado ocular en todo el mundo.
Mecanismo de Accion: Anti-Edema y Anti-Glicacion
The periorbital area is uniquely susceptible to fluid retention due to its thin dermis and dense capillary network. Acetyl Tetrapeptide-5 works through two complementary pathways. First, it inhibits angiotensin-converting enzyme (ACE), which plays a direct role in regulating vascular permeability. By reducing ACE activity, the peptide limits plasma leakage from capillaries into the surrounding tissue, directly addressing the edema that manifests as under-eye bags. Second, it reduces advanced glycation end-product (AGE) formation in the extracellular matrix. Glycation cross-links collagen fibers, reducing tissue elasticity and trapping fluids – Acetyl Tetrapeptide-5 interrupts this process, helping maintain dermal flexibility around the eye contour.
Datos de Eficacia Clinica
In a controlled 60-day clinical study with 20 volunteers, a formulation containing 0.005% Acetyl Tetrapeptide-5 produced measurable improvements in two key parameters. Under-eye puffiness decreased by 32% as assessed by standardized photography and profilometric analysis. Dark circle severity scores improved by 22% based on colorimetric measurements of the periorbital area. These results were statistically significant compared to the placebo group, and participants reported noticeable improvement starting from week three of twice-daily application.
Guia de Formulacion
Acetyl Tetrapeptide-5 is water-soluble and stable across a pH range of 5.0 to 7.0. Recommended incorporation level ranges from 50 to 200 ppm in finished products. Processing temperature must stay below 40 degrees Celsius – incorporate during the cool-down phase of any emulsion process. The peptide is compatible with standard cosmetic emollients, humectants, and preservative systems. For enhanced periorbital formulations, consider combining with Dipeptide-2 (lymphatic drainage support) or Hexapeptide-9 (collagen stimulation around the eye area).
Aplicaciones Objetivo
- Eye creams and eye serums targeting puffiness and dark circles
- Under-eye hydrogel patches with sustained peptide release
- Anti-fatigue eye contour gels for morning application
- Multi-peptide eye treatments combining Dipeptide-2 and Hexapeptide-9
- Premium anti-aging regimens with dedicated eye-zone actives
Especificaciones Tecnicas
| Parametro | Valor |
|---|---|
| INCI Name | Acetyl Tetrapeptide-5 |
| CAS Number | 820959-17-9 |
| Molecular Weight | 492.53 g/mol |
| Purity (HPLC) | ≥98% |
| Solubility | Water soluble |
| Recommended pH | 5.0 – 7.0 |
| Use Level | 50 – 200 ppm |
| Storage | Below 40 C, protect from light |
Suministro de TCS NEXUS S.L.
TCS NEXUS S.L. in Valencia, Spain, produces Acetyl Tetrapeptide-5 under FDA cGMP protocols with COSMOS and ISO 45001 certifications. Each lot includes a Certificate of Analysis with HPLC purity data, mass spectrometry verification, and peptide content determination. Evaluation orders start at 1 g, with production quantities from 100 g. EU delivery is completed within 5 to 7 business days.
Preguntas Frecuentes
What makes Acetyl Tetrapeptide-5 effective for under-eye puffiness?
The peptide inhibits angiotensin-converting enzyme, which regulates vascular permeability in the periorbital capillary network. By reducing ACE activity, it limits fluid leakage from blood vessels into surrounding tissue. Clinical data shows a 32% reduction in puffiness over 60 days at just 0.005% concentration, confirming its potency at low use levels.
Can Acetyl Tetrapeptide-5 address both puffiness and dark circles?
Yes. The dual mechanism – ACE inhibition for edema reduction and anti-glycation for improved tissue elasticity – addresses both concerns simultaneously. The same clinical study demonstrated 32% puffiness reduction alongside 22% improvement in dark circle scores, making it a comprehensive periorbital active.
What is the recommended combination for a professional eye serum?
For a multi-pathway eye serum, formulators typically combine Acetyl Tetrapeptide-5 (50-200 ppm) with Dipeptide-2 for lymphatic drainage support and Hexapeptide-9 for periorbital collagen stimulation. This three-peptide approach targets fluid retention, vascular discoloration, and fine lines around the eye contour.