Where can I buy reduced Glutathione in the EU?

TCS NEXUS S.L. holds stock in Valencia, Spain and ships across the EU within 5-7 working days. Request a sample or quote through the contact form.

What is the difference between GSH and GSSG?

GSH is the reduced (active) form with a free thiol group. GSSG is the oxidised disulphide dimer. In healthy cells the GSH:GSSG ratio is around 100:1. For topical brightening, use reduced GSH as GSSG has no direct tyrosinase-inhibiting activity.

Why does my Glutathione serum turn yellow?

Yellow colour indicates thiol oxidation forming GSSG. Common causes include pH above 5, dissolved copper or iron, oxygen headspace, or addition above 40 C. Adjust pH to 4.0-5.0, use deionised water, and switch to airless packaging.

Can I combine Glutathione with vitamin C?

Yes. GSH regenerates oxidised vitamin C back to ascorbic acid. Keep combined pH at 3.5-4.5, add both in cool-down, and use airless packaging.

Glutathione (GSH Reducido) – Tripeptido Antioxidante para Iluminacion Cutanea y Detox

INCI: Glutathione | CAS: 70-18-8 | MW: 307.32 g/mol | Composition: L-glutamate, L-cysteine, glycine tripeptide

Glutathione (GSH) es el principal antioxidante intracelular en el tejido humano. Es un tripeptido lineal de L-glutamato, L-cisteina y glicina, enlazado por un enlace gamma-peptidico entre glutamato y cisteina. Cada celula nucleada lo sintetiza, pero los niveles plasmaticos disminuyen aproximadamente un 10-15% por decada despues de los 30 anos. Esa reduccion relacionada con la edad se correlaciona con mayor dano oxidativo, desintoxicacion mas lenta y cambios visibles en la piel, incluyendo pigmentacion irregular.

TCS NEXUS S.L. supplies reduced Glutathione at over 99% purity from our EU warehouse in Valencia, Spain. Standard delivery across the European Union is 5-7 working days. Samples are available on request.

Mecanismo de Accion: Iluminacion y Defensa Antioxidante

GSH affects skin pigmentation through two parallel routes. First, it directly inhibits tyrosinase, the rate-limiting enzyme in melanin production. Second, it shifts melanogenesis away from eumelanin (brown-black pigment) toward pheomelanin (yellow-red pigment), resulting in a lighter overall complexion. A 12-week randomised controlled trial (n=60) demonstrated that 500 mg/day oral GSH combined with 2% topical GSH reduced the melanin index by 15% compared to placebo.

Beyond brightening, GSH neutralises reactive oxygen species (ROS), regenerates oxidised vitamin C back to its active ascorbic acid form, and conjugates electrophilic xenobiotics via glutathione S-transferase in phase II liver detoxification. This regeneration cycle with vitamin C is why the two ingredients work well together in topical formulations.

Guia de Formulacion para GSH Topico

Reduced glutathione is not a forgiving raw material. The free thiol group on cysteine oxidises rapidly in the presence of dissolved oxygen, metal ions or alkaline pH. A serum that starts water-white can turn yellow within days if these variables are not controlled.

Parametro	Recommendation
Use level	0.1-0.5% (typical serum range 0.2-0.5%)
pH	4.0-6.0 (thiol stability window)
Addition temperature	Cool-down phase, below 45 C
Packaging	Airless pump, opaque container mandatory
Incompatibilities	Strong oxidisers, copper ions (catalyse GSH oxidation), pH above 6
Synergy	Vitamin C (ascorbic acid) – GSH regenerates oxidised vitamin C
Storage (raw material)	2-8 C, nitrogen-flushed packaging preferred

Practical note: If your GSH serum turns yellow, that colour comes from the formation of glutathione disulphide (GSSG) and mixed disulphides. Check your water quality for dissolved metals, verify pH is below 5.0, and confirm your filling line purges headspace with nitrogen. Switching to airless packaging alone often resolves the issue.

Ingredientes Relacionados de TCS NEXUS

Glutathione Oxidized (GSSG) – The oxidised disulphide form. Used as a redox standard and in formulations studying or leveraging the GSH/GSSG ratio.
Ergothioneine – A diet-derived thione antioxidant that accumulates in high-stress tissues. Pairs with GSH in multi-layer antioxidant strategies.
Ectoin – An extremolyte osmolyte for barrier repair and sensitive skin. Complements GSH in urban-defence and anti-pollution product concepts.

Preguntas Frecuentes

Donde puedo comprar Glutathione reducido en la UE?

TCS NEXUS S.L. holds stock in Valencia, Spain. We ship across the European Union within 5-7 working days. Request a sample or quote through our contact form and specify the quantity and purity grade you need.

Cual es la diferencia entre GSH y GSSG?

GSH is the reduced (active) form with a free thiol group. GSSG is the oxidised disulphide dimer formed when two GSH molecules donate electrons to neutralise a free radical. In healthy cells the GSH:GSSG ratio sits around 100:1. A falling ratio signals oxidative stress. For topical brightening you want reduced GSH; GSSG has no direct tyrosinase-inhibiting activity.

Por que mi serum de Glutathione se vuelve amarillo?

Yellow discolouration indicates oxidation of the thiol group, forming GSSG and mixed disulphides. Common causes: pH above 5, dissolved copper or iron in your water, oxygen headspace in the bottle, or addition temperature above 40 C. Fix the root cause – adjust pH to 4.0-5.0, use deionised water tested for metals, switch to airless packaging, and add GSH only in the cool-down phase.

Puedo combinar Glutathione con vitamina C en la misma formula?

Yes, and there is a good biochemical reason to do so. GSH regenerates oxidised vitamin C (dehydroascorbic acid) back to ascorbic acid. In practice, keep the combined pH in the 3.5-4.5 window, add both actives in the cool-down phase, and use airless packaging. The two together provide a broader antioxidant effect than either alone.

Cual es su cantidad minima de pedido y ofrecen muestras?

We supply from small R and D sample quantities up to multi-kilogram production lots. Contact us with your project details and we will confirm pricing, lead time and any documentation (CoA, MSDS) you require.